Beriberi is caused by thiamine deficiency. Early 20th century epidemics in Japan were attributed to rice contaminated by citreoviridin mycotoxin. Our investigation of an outbreak of beriberi in Brazil showed an association of beriberi with the consumption of poor quality subsistence farming rice, although, unlike other investigators of this outbreak, we did not identify citreoviridin producing fungi in the implicated rice.
Get full access to this article
View all access options for this article.
References
1.
LonsdaleD. A review of the biochemistry, metabolism and clinical benefits of thiamin(e) and its derivatives. Evid Based Complement Alternat Med2006;3:49–59
2.
HoyumpaAM. Mechanism of vitamin deficiencies in alcoholism. Alcohol Clin Exp Res1986;10:572–81
3.
UraguchiK. Micotoxic origin of cardiac beriberi. J Stored Prod Res1969;5:27–36
4.
UenoY, UenoI. Isolation and acute toxicity of citreoviridin, a neurotoxic micotoxin of Penicillium Citreo-Viride Biourge. Jap J Exp Med1972;42:91–105
5.
OhtsuboK. Mycotoxins in foodstuffs and their biological action on mammals. Beitr Pathol Bd1973;148:213–20
SmithJE, HendersonRS. Mycotoxins and Animal Foods. London: CRC Press, 1991
8.
RosaCA, KellerKM, OliveiraAA, Production of citreoviridin by Penicillium citreonigrum strains associated with rice consumption and beriberi cases in the Maranhao State, Brazil. Food Addit Contam Part A Chem Anal Control Expo Risk Assess2009;29:1–8
9.
ChatzimichalakisPF, SamanidouVF, VerpoorteR. Development of a validated HPLC method for the determination of B-complex vitamins in pharmaceuticals and biological fluids after solid phase extraction. J Sep Sci2004;27:181–8