Spontaneous clearance of hepatitis C virus (HCV) is expected to be unlikely in pregnancy due to the relative immunosuppression and increase in viraemia that occurs. We report the first case of spontaneous clearance of hepatitis C virus (HCV) occurring in pregnancy.
GervaisA, BernuauJ, MartinotM. Decrease in serum ALT and increase in serum HCV RNA during pregnancy in women with chronic hepatitis C.J Hepatol2000; 32: 293–9
2.
FloreaniA, PaternosterD, ZappalaF. Hepatitis C virus infection in pregnancy.Br J Obstet Gynaecol1996; 103: 325–9
3.
AiroldiJ, BerghellaV. Hepatitis C and pregnancy.Obs Gyn Surv2006; 61: 666
4.
LeaR, CalderA. The immunology of pregnancy.Curr Opin Inf Dis1997; 10: 171–6
5.
PostJ, RatnarajahS, LloydA. Immunological determinants of the outcomes from primary hepatitis C infection.Cell Mol Life Sci2009; 66: 733–56
6.
RehermannB, SeeffL, HoofnagleJ. Pathogenesis, natural history, treatment and prevention of hepatitis C.Ann Int Med2000; 132: 296–304
GhanyM, StraderD, ThomasD, SeeffL. Diagnosis, management, and treatment of hepatitis C: an update.Hepatology.2009; 49: 1335–74
9.
ZeinC, Abu-LebdehH, ZeinN. Spontaneous clearance of chronic hepatitis C during pregnancy.Am J Gastro2001; 96: 3044
10.
NephewK, McClureK, DayM. Effects of intramuscular administration of recombinant bovine interferon alpha during the period of maternal recognition of pregnancy.J Anim Sci1990; 68: 2766–70
11.
FermV, WillhiteC, KilhamL. Teratogenic effects of ribavirin on hamster and rat embryos.Teratology.1978; 17: 93–101
12.
SpencerJD, LattN, BebbyP. Transmission of hepatitis C virus to infants of human immunodeficiency virus negative intravenous drug-using mothers: rate of infection and assessment of risk factors for transmission.J Viral Hepat1997; 4: 395–409
13.
RestiM, AzzariC, GalliL. Maternal drug use is a predominant risk factor for mother-to-child hepatitis C virus transmission: results from a multicenter study of 1372 mother-infant pairs.J Infect Dis2002; 185: 567–72
14.
RobertsE, YuengL. Maternal-Infant Transmission of Hepatitis C Virus Infection.Hepatology2002; 36: 106–113
15.
DoreG, KaldoreJ, McCaughanG. Systematic review of role of polymerase chain reaction in defining infectiousness among people infected with hepatitis C virus.BMJ1997; 315: 333–7
