The limb-girdle muscular dystrophies (LGMDs) are a group of genetically determined disorders of skeletal muscle, predominantly affecting the pelvic and shoulder-girdle musculature. The clinical course is variable but steadily progressive. Type 2A LGMD is the most frequent form, accounting for approximately 30% of identified cases. There are few reports of patients with Type 2A LGMD undergoing pregnancy and delivery. This case outlines a successful vaginal delivery in a woman with this condition.
BushbyK. Diagnosis and management of the limb girdle muscular dystrophies. Pract Neurol2009;9:314–23
4.
ZatzM, StarlingA. Calpains and disease. N Engl J Med2005;352:2413
5.
BertipagliaI, BourgN, RichardI, A proteomic study of calpain-3 and its involvement in limb girdle muscular dystrophy Type 2A. Cell Calcium2009;46:356–63
6.
BonnemannC. Limb-girdle muscular dystrophy in childhood. Paediatr Ann2005;34:569–77
7.
BeckmanJ, BushbyK. Advances in the molecular genetics of the limb-girdle type of autosomal recessive progressive muscular dystrophy. Curr Opin Neurol1996;9:389–93
8.
KirschnerJ, BonnemannC. The congenital and limb-girdle muscular dystrophies: sharpening the focus, blurring the boundaries. Arch Neurol2004;61:189
9.
Rudnik-SchonebornS, GlaunerB, RohrogD, ZerresK. Obstetric aspects in women with fascioscapulohumeral muscular dystrophy, limb-girdle muscular dystrophy and congenital myopathies. Arch Neurol1997;54:888–94
10.
PashM, BalatonJ, EagleC. Anaesthetic management of a parturient with severe muscular dystrophy, lumbar lordosis and a difficult airway. Canad J Anaesth1996;43:959–63
11.
AllenT, MaguireS. Anaesthetic management of a woman with autosomal recessive limb-girdle muscular dystrophy for emergency caesarean section. Int J Obstetr Anaesth2007;16:370–4
12.
ShneersonJ. Pregnancy in neuromuscular and skeletal disorders. Monaldi Arch Chest Dis1994;49:227–30
13.
AyoubiJ, MeddounM, JoukP, FavierM, PonsJ. Vaginal delivery in a woman with limb-girdle muscular dystrophy: a case report. J Reprod Med2000;45:498–500
