Metronidazole is the drug of choice for invasive amoebiasis; however, it is not known whether its dose or duration require modification in HIV infection when treating invasive amoebiasis. Seven HIV-positive patients with acute phase amoebic liver abscess were treated with daily oral administration of 1500 mg of metronidazole for 10 days. None of the patients required abscess drainage, and metronidazole was effective in all patients without serious side-effects. The CD4 cell count or HIV viral load did not appear to influence the efficacy of metronidazole therapy.
LowtherSA, DworkinMS, HansonDL. Adult and Adolescent Spectrum of HIV Disease Project. Entamoeba histolytica/Entamoeba dispar infections in human immunodeficiency virus-infected patients in the United States. Clin Infect Dis2000;30:955–9
2.
BrindicciG, PicciarelliC, FumarolaL, Amoebic hepatic abscesses in an HIV-positive patient. AIDS Patient Care STDS2006;20:606–11
3.
GattiS, CeviniC, AtzoriC, Non-pathogenic Entamoeba histolytica in Italian HIV-infected homosexuals. Zbl Bakt1992;277:382–8
4.
MoránP, RamosF, RamiroM, CurielO, GonzálezE, ValadezA. Infection by human immunodeficiency virus-1 is not a risk factor for amebiasis. Am J Trop Med Hyg2005;73:296–300
5.
HungC, DengH, HsiaoW, Invasive amebiasis as an emerging parasitic disease in patients with human immunodeficiency virus type 1 infection in Taiwan. Arch Intern Med2005;165:409–15
6.
OhnishiK, KatoY, ImamuraA, Present characteristics of symptomatic. Entamoeba histolytica infection in big cities of Japan. Epidemiol Infect2003;132:57–60
7.
ParkW, ChoeP, JoJ, Amebic liver abscess in HIV-infected patients, Republic of Korea. Emerg Infect Dis2007;13:516–7
8.
WiwanitkitV. Causative agents of liver abscess in HIV-seropositive patients: a 10-year case series in Thai hospitalized patients. Trop Doct2005;35:115–7
9.
Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Japan. Amebiasis in Japan, 2003–2006. Infect Agents Surveil Rep2007;28:103–4
10.
Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Japan. The topic of this month. HIV/AIDS in Japan, 2007. Infect Agents Surveil Rep2008;29:145–6
11.
GhadirianE, MeerovitchE. Effect of immunosuppression on the size and metastasis of amoebic liver abscesses in hamsters. Parasite Immunol1981;3:329–8
12.
HouptER, GlembockiDJ, ObrigTG, The mouse model of amebic colitis reveals mouse strain susceptibility to infection and exacerbation of disease by CD4+ T cells. J Immunol2002;169:4496–503
13.
OhM, LeeK, KimE, Amoebic liver abscess in HIV-infected patients.AIDS2000;14:1872–3
14.
MitaraiS, NagaiH, SatohK, HebisawaA, ShishidoH. Amebiasis in Japanese homosexual men with human immunodeficiency virus infections. Int Med2001;40:671–5
