The discovery of phagocytosis is associated indelibly with Elie Metchnikoff, who coined the term, but more than 30 persons had observed the phenomenon (or inferred its existence) before Metchnikoff came to dominate the field. Two of these early investigators were William Osler and George Miller Sternberg. Osler recognized carbon particles within the phagocytes of patients with miner's lung and carried out experiments in kittens. Sternberg only theorized about phagocytosis but, unlike Osler, bitterly contested Metchnikoff's priority of discovery.
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References
1.
AmbroseCT. The Osler slide, a demonstration of phagocytosis from 1876; reports of phagocytosis before Metchnikoff's 1880 paper. Cellular Immunology: 2006; 240: 1-4
2.
OslerW. On the pathology of miner's lung. Canada Medical and Surgical Journal1875; 4: 145-68
3.
RosenR. Osler on miner's phthisis. Journal of the History of Medicine1949; 4: 262-3
4.
RosenR. The History of Miners’ Diseases. A Medical and Social Interpretation.New York: Schuman's, 1943: p. 375and Plate III
5.
OslerW (op. cit. ref. 2): p. 145
6.
Ibid.: p. 149
7.
RodinAE. Oslerian Pathology, an Assessment and Annotated Atlas of Museum Specimens.Galveston, Texas: Coronado Press, 1981: p. 86
8.
The slide was found by FraserDr Rick, Department of Pathology, McGill University who determined that it had been prepared in 1876-77 by a medical student ‘as part of a course in histology then taught by Osler.’ Personal communication to the author, 17 September 2005. The slide is part of the ‘Greenwood Collection’ of the Medical Historical Museum at McGill University and is described in another publication (Ambrose CT (op. cit. ref. 1))
9.
OslerW (op. cit. ref. 2): pp. 164-5
10.
Ibid.: p. 163
11.
Some of the narrative in this section has been used in another paper that describes Osler's work relative to other students of phagocytosis who also predate Metchnikoff's involvement in the field (Ambrose CT (op. cit. ref. 1))
12.
JamesGH, HirschBI. Metchnikoff's life and scientific contributions in historical perspective. In: KarnovskyML, BolisL, eds. Phagocytosis Past and Future.New York: Academic Press, 1982: p. 3
13.
BriegerGH. Introduction. In: Binnie FG, trans. Immunity in Infective Diseases.New York: Johnson Reprint Corp, 1968: ix-xxxi
14.
MetchnikoffE. Über die intracelluäre Verdauung bei Coelenteraten. Zoologischer Anzeiger1880; 3: 261-3
15.
BriegerGH (op. cit. ref. 12): p. xxiii
16.
MetchnikoffE. Untersuchungen über die intracelluläre Verdauung bei wirbellosen hieren. Arbeiten aus dem Zoologischen Instituten der Universität Wien und der Zoologischen Station in Triest1883; 2: 164-5
17.
MetschnikoffE. Über eine Sprosspilzkrankheit der Daphnien; Beitrag zur Lehre über den Kamp der Phagocyten gegen Krankheitserreger. Archiv für pathologische Anatomie und Physiologie und für klinische Median1884; 96: 177-95
18.
MetschnikoffE. Über den Phagocytenkampt bei Rückfalltyphus. Virchow's Archiv1887; 109: 176-92
19.
MetchnikoffE. Works of Elie Metchnikoff. In: Lectures on the Comparative Pathology of Inflammation.New York: Dover Publications, Inc, 1968: 213-18
20.
TauberAI. The birth of immunology. III. The fate of the phagocytosis theory. Cellular Immunology1992; 139: 520-7
21.
SternbergML. George Miller Sternberg, A Biography.Chicago: American Medical Association, 1920. (This is a biography by Sternberg's second wife, Martha L Sternberg)
22.
GibsonJM. Soldier in White, The Life of General George Miller Sternberg.Durham, NC: Duke University Press, 1958
23.
SternbergGW. Bacteria, Including 152 Pages from the Work of Dr. Antoine Magnin, Translated from the French.New York: William Wood & Co, 1880
24.
SternbergGW. A Manual of Bacteriology.New York: William Wood & Co, 1892
25.
SternbergGW. A Textbook of Bacteriology.New York: William Wood & Co, 1901
26.
SternbergGW. Immunity, Protective Inoculation in Infectious Diseases and Serum-Therapy.New York: William Wood & Co, 1895
27.
SternbergGW. Infection and Immunity with Special Reference to the Prevention of Infectious Diseases.New York: GP Putnam's Sons, 1907
28.
KellyHA. George Miller Sternberg, 1838-1915. Bulletin of the Johns Hopkins Hospital1921; 32: 1-5
29.
SternbergGW. The Metchnikoff theory. Journal of the American Medical Association1914; 63: 1779-80
30.
SternbergGW. Contribution to the study of the bacterial organisms commonly found upon exposed mucous surfaces and in the alimentary canal of healthy individuals. Transactions of the American Association for the Advancement of Science1881; 30: 83-94
31.
SternbergGW (op. cit. ref. 24): pp. 245-6
32.
SternbergGW (op. cit ref. 30): pp. 83-94
33.
SternbergGW. A fatal form of septicaemia in the rabbit, produced by the subcutaneous injection of human saliva. Report of the National Board of Health1881; 2: 87-92
34.
SternbergGW (op. cit. ref. 29): pp. 1779-1780
35.
MetchnikoffE. Über die Beziehung der Phagocyten zu Milzbrandbacillen. Virchow's Archiv1884; 97: 502-26
36.
MetchnikoffE (op. cit. ref. 14): pp. 261-3
37.
AmbroseCT (op. cit. ref. 1)
38.
TauberAI (op. cit. ref. 20): pp. 510-5
39.
WelchWH. The Micrococcus lanceolatus, with especial reference to the aetiology of acute lobar pneumonia. Bulletin of the Johns Hopkins Hospital1892; 27: 125-6
40.
PasteurL. Sur une maladie nouvelle, provoquée par la salive d'un enfant mort de la rage. Comptes Rendus de l'Academie des Sciences1881; 92: 159-65
41.
SternbergGW (op. cit. ref. 33): pp. 89-90
42.
SternbergGW (op. cit. ref. 24): p. 293, 298
43.
Ibid.: p. 298
44.
SternbergGW (op. cit. ref. 25): p. 339
45.
WarnerM. Hunting the yellow fever germ: the principle and practice of etiological proof in late nineteenth-century America. Bulletin of the History of Medicine1985; 59: 361-382
46.
SternbergGW (op. cit. ref. 24): pp. 529-32
47.
HarveyAM. Johns Hopkins and yellow fever: a story of tragedy and triumph. Johns Hopkins Medical Journal$198;149: 25-39
48.
WarnerM (op. cit. ref. 45): p. 374
49.
Editors. SanarelliSternberg vs. Georgia Journal of Medicine and Surgery1897; 1: 236-7
50.
HemmeterJC. Major James Carroll of the United States Army, Yellow Fever Commission, and the discovery of the transmission of yellow fever by the bite of the mosquito ‘Stegomyia fasciata’. Janus1908; 13: 57-72, 150-76
51.
BeanWB. Walter Reed and yellow fever. Journal of the American Medical Association1983; 250: 659-62
52.
BolletAJ. Plagues & Poxes, the Impact of Human History on Epidemic Disease.New York: Domo Medical Publishing, Inc, 2004: p. 60
53.
DukeGM (op. cit. ref. 22): p. 237
54.
BeanWB (op. cit. ref. 51): p. 62
55.
De KruifP. Microbe Hunters.New York: Harcourt, Brace and Co, 1926
56.
ShawB. The Doctor's Dilemma.Baltimore: Penguin Books, 1965
57.
PeinerL.Elie Metchnikoff, Ph.D. (1845-1916). New York State Journal of Medicine1969; 69: 2371-6
58.
VaughanRB. The romantic rationalist, a study of Elie Metchnikoff. Medical History1965; 9: 201-15
59.
BriegerGH (op. cit. ref. 13): p. xxix
60.
VaughanRB (op. cit. ref. 57): pp. 208-9
61.
MetchnikoffE (op. cit. ref. 19): pp. 210-1
62.
BibelDJ. Sternberg, Metchnikoff, and the phagocytes. Military Medicine1982; 147: 550-3
63.
OslerW. On phagocytes. The Medical News1889; 54: 393-6, 421-5
64.
Ibid.: p. 425
65.
CushingH. The Life of Sir William Osler.London: Oxford University Press, 1940: vol. I, p. 332
66.
OslerW. On the pathology of the so-called pig-typhoid. The Veterinary Journal and Annals of Comparative Pathology1878; 6: 385-403
67.
OslerW, ClementAW. Cestode tuberculosis: a successful experiment in producing it in the calf. American Veterinary Review1882; 6: 6-10
68.
OslerW, ClementAW. An investigation into the parasites in the pork supply of Montreal. Canada Medical and Surgical Journal1882-1883;11: 325-36
69.
MacCallumWG. Osler as a pathologist. Johns Hopkins Hospital Bulletin1919; 30: 197-8
70.
WelchWH. Foreword: William Osler. In: AbbottM, ed. Sir William Osler memorial number. Bulletin No. IX of the International Association of Medical Museums and Journal of Technical Methods.Montreal, Canada: Privately printed, 1926: p. i-xi
71.
CushingH (op. cit. ref. 65): vol. II, pp. 397-8, 434-5
72.
CushingH (op. cit. ref. 65): vol. II, p. 108
73.
Ibid.: p. 645
74.
BondyPK. What's so special about Osler?Yale Journal of Biology and Medicine1980; 53: 213-17
75.
OslerW. Unity, peace and concord. Journal of the American Medical Association1905; 45: 365-9
76.
GouldSJ. Ontogeny and Phylogeny.Cambridge, MA: Harvard University Press, 1977: p. 35
77.
DubosRJ. Louis Pasteur, Free Lance of Science.Boston: Little, Brown and Co, 1950: p. 82
78.
AllbuttAC, Proem: William Osler. In: AbbottM, ed., Sir William Osler memorial number. Bulletin No. IX of the International Association of Medical Museums and Journal of Technical Methods.Montreal, Canada: Privately printed, 1926: xiii-viii
79.
OslerW. An Alabama Student and Other Biographical Essays.London: Oxford University Press, 1908: p. 61
