Limited information is currently available on patient preferences regarding administration frequency, tablet load and the trade-off between side effects and convenience in choosing antiretroviral regimens. A standardized questionnaire of persons with HIV infection across 5 large European countries was used to assess patient preference. 504 people with HIV participated. Participants showed a preference for once-daily therapy administration. However, several factors affected this preference.
SauneI, CahnP, PercivalLComparative results (Phase II 48-Week): BMS-232632, stavudine, lamivudine as HAART for treatment-naïve HIV(+) patients (AI424-008) [Poster I-667], 41st Inter science Conference on Antimicrobial Agents and Chemotherapy, Chicago 2001
2.
Van LethF, HassinckE, PhanuphakPResults of the 2NN Study: A randomized comparative trial of 1st line antiretroviral therapy (ART) with regimens containing either nevirapine (NVP) alone, efavirenz (EFV) alone or both drugs combined together with stavudine and lamivudine. (2NN Study) [Abstract No. 176]. 10th Conference on Retroviruses and Opportunistic Infections, Boston 2003
3.
SquiresKE, ThiryA, GiordanoMAtazanavir (ATV) QD vs efavirenz (EFV) QD with fixed-dose ZDV+3TC BID: Comparison of antiviral efficacy and safety 48-week results from BMS AI424-034 Phase III Pivotal Study [Abstract H-1076]. 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego 2002
4.
ClaxtonAJ, CramerJ, PierceC. A systematic review of the associations between dose regimens and medication compliance.Clin Ther2001; 23: 1296310
5.
BassD, SmithMF. HIV patients prefer once-daily regimens [Abstract MOPeB3290]. XIV International AIDS Conference, Barcelona 2002
6.
GiffordAL, BormannJE, ShivelyMJPredictors of self-reported adherence and plasma HIV concentrations in patients on multidrug antiretroviral regimens.J Acquir Immunol Defic Syndr2000; 23: 38695
7.
WalshJC, HomeR, DaltonMReasons for non-adherence to antiretroviral therapy: patients’ perspectives provide evidence of multiple causes.AIDS Care2001; 13: 70920
8.
Park-WyllieLY, ScaleraA, TsengAHigh rate of discontinuations of highly active antiretroviral therapy as a result of antiretroviral intolerance in clinical practice: missed opportunities for adherence support?AIDS2002; 16: 10846
9.
The AWARE Talk Radio Poll; 2001-2002; The AIDS Talk Radio Project in conjunction with The Core Center; AIDS Research Alliance; Howard Brown Health Center; an Internet survey.Chicago: Howard Brown Health Center, 2002
10.
BartlettJA, DeMasiR, QuinnJOverview of the effectiveness of triple combination therapy in antiretroviral naïve HIV-1 infected adults.AIDS15: 136977
11.
MaggioloF, AriciC, GregisGPA controlled, randomised, prospective study on a once-a-day therapy for HIV infection [Abstract H-163]. 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego 2002
12.
FischlMA, CastroJ, MonroigRImpact of directly observed therapy on long-term outcomes in HIV clinical trials [Abstract 528]. 8th Conference on Retroviruses and Opportunistic Infections, Chicago 2001
