Abstract
Pregnancy-associated murine protein-1 (PAMP-1) could not be detected in peripheral blood of female dwarf mice (genotype dw/dw of the DW strain). By contrast the normal size females of the DW strain (genotypes +/+ and +/dw) had PAMP-1 serum levels of 18·9 AU ± 15·7 AU/ml. Following administration of biosynthetic human growth hormone (hGH) every 2h for 52 h PAMP-1 was detected in all dwarf females at concentrations of 16·0 AU ± 3·3 AU/ml.
The albumin levels in the circulation of DW females of normal size were significantly higher (P<0·05) than those of DW dwarfs, and the hGH administration did not change the serum albumin levels.
The present experiment adds weight to the suggestion that the PAMP-1 serum level is regulated by GH.