2 commercially-produced maintenance diets containing crude protein levels of 14-15 and 21% were offered to normal mice and normal and thymectomized rats for 48-52 weeks. Both sexes of 2 strains of mouse, CBA/Ca and BALB/c, and 2 strains of rat, Wistar males and Lister Hooded females, were used, starting at 8-10 weeks of age.
Results indicated that the diet containing 14-15% crude protein was an acceptable substitute for the 21% protein diet and could reduce the dietary cost by 30-40%.
References
1.
ClarkeH. E., CoatesM. E., EvaJ. K., FordD. J., MilnerC. K., O'DonoghueP. N., ScottP. P. & WardR. J. (1977). Dietary standards for laboratory animals: report of the Laboratory Animals Centre Diets Advisory Committee. Laboratory Animals11, 1-28.
2.
CoatesM. E., O'DonoghueP. N., PayneP. R. & WardR. J. (1969). Dietary standards for laboratory rats and mice. Laboratory Animals Handbook2, 9.
3.
de WardenerH. E. (1973). The kidneys, 4th ed., p. 201. Edinburgh: Churchill Livingstone.
4.
DunnT. B. (1944). Relationship of amyloid infiltration and renal disease in mice. Journal of the National Cancer Institute5, 17-27.
5.
DunnT. B. (1948). Some observations of the normal and pathologic anatomy of the kidney of the mouse. Journal of the National Cancer Institute9, 285-301.
6.
DunnT. B. (1967). Amyloidosis in mice. In Pathology of laboratory rats and mice (ed. CotchinE., & RoeF. J. C.), pp. 195-197. Oxford: Blackwell.
7.
GanzinM. (1975). Present and future world protein supplies. Folia veterinaria latina6, supplement 1, 43.
8.
GorerP. A. (1940). Renal lesions found in pure lines of mice. Journal of Pathology and Bacteriology50, 25-30.
9.
MillerJ. F. A. P. (1960). Studies on mouse leukaemia. The role of the thymus in leukaemogenesis by cell-free leukaemic filtrates. British Journal of Cancer14, 93-98.
10.
MRC (1974). The Accreditation and Recognition Schemes for suppliers of laboratory animals. Medical Research Council Laboratory Animals Centre, Manual Series I, 2nd ed.
11.
WhiteF. R. (1961). The relationship between underfeeding and tumor formation, transplantation and growth in rats and mice. Cancer Research21, 281-290.
