In juvenile wild rats, bronchus-associated lymphoid tissue (BALT) development was similar to that seen in adult specified-pathogen-free rats. In adult wild rats the BALT was widespread. In one animal infected with a mycoplasma-like organism, a region of bronchoepithelium overlying a large BALT nodule was seen, through which lymphocytes appeared able to pass to make direct contact with the bronchial lumen: the significance of this observation is discussed. There was no evidence of infection in lungs from any of the specified-pathogen-free animals, where small foci of BALT were seen.
References
1.
BienenstockJ., JohnstonN., & PereyD. Y. E. (1973a). Bronchial lymphoid tissue. I. Morphological characteristics. Laboratory Investigations28, 686–692.
2.
BeinenstockJ., JohnstonN., & PereyD. Y. E. (1973b). Bronchial lymphoid tissue. II. Functional characteristics. Laboratory Investigations28, 693–698.
3.
BienenstockJ., & JohnstonN. (1976). A morphological study of rabbit bronchial lymphoid aggregates and lympho-epithelium. Laboratory Investigation35, 343–348.
4.
BrundeletP. N. (1965). Experimental study of the dust-clearance mechanism of the lung. Acta pathologica et microbiologica scandinavica Supplement 175.
5.
ChamberlainD. W., NopajaroonsriC., & SimonG. T. (1973). Ultrastructure of the pulmonary lymphoid tissue. American Review of Respiratory Diseases108, 621–631.
6.
GiddensW. E., WhitehairC. K., & CarterG. R. (1971). Morphologic and microbiologic features of trachea and lungs in germfree, defined-flora, conventional and chronic respiratory disease affected rats. American Journal of Veterinary Research32, 115–129.
7.
JerichoK. W. F., AustwickP. K. C., HedgesR. T., & DixonJ. B. (1971). Intrapulmonary lymphoid tissue of pigs exposed to aerosols of carbon particles, of Salmonella oranienburg, of Mycoplasma granularum, and to an oral innoculum of larvae of Metastrongylus apri. Journal of Comparative Pathology81, 13–21.
8.
LambD. (1975) Rat lung pathology and quality of laboratory animals: the user's view. Laboratory Animals9, 1–8.
9.
MacklinC. C. (1955). Pulmonary sumps, dust accumulations, alveolar fluid and lymph vessels. Acta anatomica23, 1–33.
10.
von SeebachH. B., & SchöelerK. (1970). Das lympho-epitheliale system der Rattenlunge bei experimenteller Quartzstaub-Belastung. Virchows Archiv fiir patho-logische Anatomie und Physiologie und für Klinische Medizin. Abteilung A350, 205–215.
