Evidence for a Mechanism of Teratogenesis Involving Inhibition of Embryotrophic Nutrition

Ancel P. , & Lallemand S. (1941). Sur l'arrêt de développement du bourgeon caudal obtenu expérimentalement chez l'embryon de poulet. Arch. Phys. biol. 15, Suppl. 43, 27.

Barber A. N. , & Geer J. C. (1964). Studies on the teratogenic properties of trypan blue and its components in mice. J. Embryol. exp. Morph. 12, 1.

Beaudoin A. R. (1961). Teratogenic activity of several closely related disazo dyes on the developing chick embryo. J. Embryol. exp. Morph. 9, 14.

Beaudoin A. R. , & Wilson J. G. (1958). Teratogenic effects of trypan blue on the developing chick. Proc. Soc. exp. Biol. Med. 97, 85.

Beck F. (1965). The distribution of acid phosphatase in the chick blastoderm. Expl Cell Res. 37, 504.

Beck F. , & Lloyd J. B. (1963). The preparation and teratogenic properties of pure trypan blue and its common contaminants. J. Embryol. exp. Morph. 11, 175.

Beck F. , & Lloyd J. B. (1964). Dosage-response curves for the teratogenic activity of trypan blue. Nature, Lond. 201, 1136.

Beck F. , & Lloyd J. B. (1965). Embryological principles of teratogenesis. In Embryopathic activity of drugs (eds Robson J. M. , Sullivan F. , & Smith R. L. ), p. 1. London: Churchill.

Beck F. , & Lloyd J. B. (1966). The teratogenic effects of azo dyes. In Advances in teratology (ed. Wollam D. H. M. ), vol. 1, p. 131. London & New York: Academic Press.

Beck F. , & Lloyd J. B. (1968). Methods for the study of embryotrophic nutrition. Lab. Anim. 2, 157.

Beck F. , Lloyd J. B. , & Griffiths A. (1967). Lysosomal enzyme inhibition by trypan blue: a theory of teratogenesis. Science, N.Y. 157, 1180.

Beck F. , Parry L. M. , & Lloyd J. B. (1967). An electron microscopic study of lysosomes in the rat yolk sac. J. Anat. 102, 141.

Bertini F. , Mego J. L. , & McQueen J. D. (1967). Distribution in tissue homogenates, and the nature of the linkage of injected proteins to subcellular particles. J. cell. Physiol. 70, 105.

Christie G. A. (1965). Teratogenic effects of synthetic compounds related to trypan blue: the effect of 1, 7-diamino-8-naphthol-3, 6-disulphonic acid on pregnancy in the rat. Nature, Lond. 208, 1219.

Critchfield C. , & Daniel J. C. (1965). Teratogenic effects of trypan blue on the Coturnix quail when injected into the mother. Growth 29, 301.

Davis H. W. , & Guneberg D. L. (1968). Trypan blue in the rat embryo. Teratology 1, 125.

De Duve C. (1968). Lysosomes as targets for drugs. In The interaction of drugs and subcellular components in animal cells (ed. Campbell P. N. ), p. 155. London: Churchill.

De Duve C. , & Wattiaux R. (1966). Functions of lysosomes. A. Rev. Physiol. 28, 435.

Fouts J. R. , Kamm J. J. , & Brodie B. B. (1957). Enzymatic reduction of prontosil and other azo dyes. J. Pharmac. exp. Ther. 120, 291.

Gillman J. , Gilbert C. , Gillman T. , & Spence I. (1948). A preliminary report on hydrocephalus, spina bifida and other congenital anomalies in the rat produced by trypan blue. S. Afr. J. med. Sci. 13, 47.

Giroud A. (1968). Nutrition of the embryo. Fedn Proc. Fedn Am. Socs exp. Biol. 27, 163.

Griffiths A. , Lloyd J. B. , & Beck F. (1966). Inhibition of lysosomal acid phosphatase by trypan blue. Biochem. J. 100, 45P.

Krzyzowska-Gruca S. , & Schiebler T. H. (1967). Experimentelle Untersuchungen am Dottersackepithel der Ratte. Z. Zellforsch, mikrosk. Anat. 79, 157.

Lloyd J. B. , & Beck F. (1963). An evaluation of acid disazo dyes by chloride determination and paper chromatography. Slain Technol. 38, 165.

Lloyd J. B. , & Beck F. (1964). The identification of some acid disazo dyes by paper electrophoresis of their reduction products. Stain Technol. 39, 7.

Lloyd J. B. , & Beck F. (1966). The relationship of chemical structure to teratogenic activity among bisazo dyes: a re-evaluation. J. Embryol. exp. Morph. 16, 29.

Lloyd J. B. , & Beck F. (1968). The mechanism of teratogenic action of trypan blue. In Proceedings of the International Symposium on Teratology, Como, 1967. Amsterdam: Excerpta Medica Foundation.

Lloyd J. B. , & Beck F. (1969). Teratogenesis. In Lysosomes in biology and pathology (eds Fell H. B. , & Dingle J. T. ). Amsterdam: North Holland.

Lloyd J. B. , Beck F. , Griffiths A. , & Parry L. M. (1968). The mechanism of action of acid bisazo dyes. In The interaction of drugs and subcellular components in animal cells (ed. Campbell P. N. ), p. 171. London: Churchill.

Mego J. L. , Bertini F. , & McQueen J. D. (1967). The use of formaldehyde-treated ¹³¹I-albumin in the study of digestive vacuoles and some properties of these particles from mouse liver. J. Cell Biol. 32, 699.

Mego J. L. , & McQueen J. D. (1967). Heterolysosome formation in mouse liver. J. cell. Physiol. 70, 115.

Mulherkar L. (1960). The effects of trypan blue on chick embryos cultured in vitro. J. Embryol. exp. Morph. 8, 1.

Roxon J. J. , Ryan A. J. , & Wright S. E. (1966). Reduction of tartrazine by a Proteus species isolated from rats. Fd Cosmet. Toxicol. 4, 419.

Trump B. F. (1961). An electron microscope study of the uptake, transport, and storage of colloidal materials by the cells of the vertebrate nephron. J. Ultrastruct. Res. 5, 291.

Turbow M. M. (1966). Trypan blue induced teratogenesis of rat embryos cultivated in vitro. J. Embryol. exp. Morph. 15, 387.

Wilson J. G. (1965). Embryological considerations in teratology. Ann. N.Y. Acad. Sci. 123, 219.

Wilson J. G. , Beaudoin A. R. , & Free H. J. (1959). Studies on the mechanism of teratogenic action of trypan blue. Anat. Rec. 133, 115.

Wilson J. G. , Shepard T. H. , & Gennaro J. F. (1963). Studies on the site of teratogenic action of C¹⁴-labeled trypan blue. Anat. Rec. 145, 300.