Extensive haemorrhage which could be prevented by vitamin K, or by bacterial contamination of the animals, has been reported in germ-free rats fed purified diets by Gustafsson (1959a; 1959b). As far as we are aware a similar vitamin K deficiency has not previously been reported in rats of limited microflora ('SPF').
References
1.
GustafssonB. E. (1959a). Vitamin K deficiency in germ-free rats. Ann. N.Y. Acad. Sci.78, 166.
2.
GustafssonB. E. (1959b). (Discussion during symposium on germ-free animals). Recent Prog. Microbiol.7, 365.
3.
LucasO. N., & JaquesL. B. (1964). Effects of E-A.C.A. in spontaneous haemorrhage due to stress with anticoagulants in rats. Can. J. Physiol. Pharmac.42, 803.
4.
LucasO. N., MillarG. J., & JaquesL. B. (1965). Experimental haemorrhage due to stress followed by anticoagulants in rats: lack of protection by CNS depressants. Acta physiol. latinoam.15, 285.
