The angiotensin II type 2 receptor gene polymorphism and body mass index in healthy Japanese women

Abstract

Background: Angiotensin II (AngII), through the AngII type 2 receptor (AT₂-R), might exert some effect on adipocyte-and lipogenesis-related biology. The Adenine/Cytosine 3123 (A/C³¹²³) polymorphism in the AT₂-R gene is reportedly involved in some diseases, such as hypertension.

Methods: A total of 201 healthy Japanese women (mean age 43.2 years) were enrolled in the study to investigate the association among the AT₂-R A/C³¹²³ polymorphism detected by polymerase chain reaction methods, body mass index (BMI) and other obesity-linked metabolic parameters (blood pressure, serum lipid/lipoprotein, plasma glucose).

Results: Homozygotes of the C-allele in the AT₂-R A/C³¹²³ polymorphism were associated with small but significant increases in BMI levels. There were no differences between genotype-based groups in the obesity-linked metabolic parameters.

Conclusion: These findings suggest that the AT₂-R A/C³¹²³ polymorphism could be a polymorphic marker related to BMI in Japanese women.