Near infrared (NIR) spectroscopy will play an increasingly important role in pharmaceutical processes as the quality of pharmaceutical products is progressively defined on the basis of their performance and pharmaceutical quality control is transformed to meet this challenge. This new quality control will require a thorough understanding of the sources of error in NIR methods, an understanding that starts with fundamentals such as the physics of diffuse reflectance and the Theory of Sampling, and progresses to working with pharmaceutical engineers to implement online predictions and control of pharmaceutical operations. This article outlines the research areas that need to be integrated to advance the implementation of NIR spectroscopy in the pharmaceutical industry.
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