This short review summarizes recent and projected advances in Fourier transform ion cyclotron resonance mass spectrometry instrumentation and applications, ranging from petroleomics to proteomics. More details are available from the cited primary literature and topical reviews.
MarshallA.G.HendricksonC.L.JacksonG.S., “Fourier Transform Ion Cyclotron Resonance Mass Spectrometry: A Primer”, Mass Spectrom. Rev.17, 1–35 (1998). doi: 10.1002/(SICI)1098-2787(1998)17:1<1::AID-MAS1>3.0.CO;2-K
2.
MarshallA.G.RodgersR.P., “Petroleomics: The Next Grand Challenge for Chemical Analysis”, Acc. Chem. Res.37, 53–59 (2004). doi: 10.1021/ar020177t
3.
RodgersR.P.SchaubT.M.MarshallA.G., “Petroleomics: Mass Spectrometry Returns To Its Roots”, Anal. Chem.77, 20A–27A (2005). doi: 10.1021/ac0492362
4.
StensonA.C.MarshallA.G.CooperW.T., “Exact Masses and Chemical Formulas of Individual Suwannee River Fulvic Acids from Ultrahigh Resolution Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectra”, Anal. Chem.75, 1275–1284 (2003). doi: 10.1021/ac026106p
5.
HeF.EmmettM.R.HåkanssonK.HendricksonC.L.MarshallA.G., “Theoretical and Experimental Prospects for Protein Identification Based Solely on Accurate Mass Measurement”, J. Proteome Res.3, 61–67 (2004). doi: 10.1021/pr034058z
6.
ChalmersM.J.KolchW.EmmettM.R.MarshallA.G.MischakH., “Identification and Analysis of Phosphopeptides”, J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. (Special Issue: Peptide Separation and Analysis)803, 111–120 (2004). doi: 10.1016/j.jchromb.2003.09.006
7.
HåkanssonK.CooperH.J.HudginsR.R.NilssonC.L., “High Resolution Tandem Mass Spectrometry for Structural Biochemistry”, Curr. Org. Chem.7, 1503–1525 (2003).
8.
MedzihradszkyK.F.ZhangX.ChalkleyR.J.GuanS.McFarlandM.A.ChalmersM.J.MarshallA.G.DiazR.L.AllisC.D.BurlingameA.L., “Characterization of Tetrahymena Histone H2B Variants and Posttranslational Populations by Electron Capture Dissociation (ECD) Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR MS)”, Mol. Cell. Proteomics3, 872–886 (2004). doi: 10.1074/mcp.M400041-MCP200
9.
CooperH.J.HeathJ.K.JaffrayE.HayR.T.LamT.-K.T.MarshallA.G., “Identification of Sites of Ubiquitination in Proteins: A Fourier Transform Ion Cyclotron Resonance Mass Spectrometry Approach”, Anal. Chem.76, 6982–6988 (2004). doi: 10.1021/ac0401063
10.
CooperH.J.TathamM.H.JaffrayE.HeathJ.K.LamT-K.T.MarshallA.G.HayR.T., “Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for the Analysis of SUMO Modification: Identification of Lysines in RanBP2 and SUMO Targeted for Modification during the E3 AutoSUMOylation Reaction”, Anal. Chem.77, 6310–6319 (2005). doi: 10.1021/ac058019d
11.
LamT.T.LanmanJ.K.EmmettM.R.HendricksonC.L.MarshallA.G.PreveligeP.E., “Mapping of Protein: Protein Contact Surfaces by Hydrogen/Deuterium Exchange Followed by On-Line HPLC Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Analysis”, J. Chromatogr. A982, 85–95 (2002). doi: 10.1016/S0021-9673(02)01357-2
12.
OomensJ.PolferN.MooreD.T.MarshallA.G.EylerJ.R.MeijerG.von HeldenG., “Charge-State Resolved Mid-Infrared Spectroscopy of a Gas-Phase Protein”, Phys. Chem. Chem. Phys.7, 1345–1348 (2005). doi: 10.1039/b502322j
13.
ChalmersM.J.BusbyS.A.PascalB.HeY.HendricksonC.L.MarshallA.G.GriffnP.R., “Probing Protein Ligand Interactions by Automated Hydrogen/Deuterium Exchange Mass Spectrometry”, Anal. Chem.78, 1005–1014 (2006). doi: 10.1021/ac051294f
14.
SenkoM.W.HendricksonC.L.EmmettM.R.ShiS.D.-H.MarshallA.G., “External Accumulation of Ions for Enhanced Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry”, J. Am. Soc. Mass Spectrom.8, 970–976 (1997). doi: 10.1016/S1044-0305(97)00126-8
15.
WilcoxB.E.HendricksonC.L.MarshallA.G., “Improved Ion Extraction from a Linear Octopole Ion Trap: SIMION Analysis and Experimental Demonstration”, J. Am. Soc. Mass Spectrom.13, 1304–1312 (2002). doi: 10.1016/S1044-0305(02)00622-0
16.
HåkanssonK.ChalmersM.J.QuinnJ.P.McFarlandM.A.HendricksonC.L.MarshallA.G., “Combined Electron Capture and Infrared Multiphoton Dissociation for Multistage MS/MS in an FT-ICR Mass Spectrometer”, Anal. Chem.75, 3256–3262 (2003). doi: 10.1021/ac030015q
17.
BeuS.C.BlakneyG.T.QuinnJ.P.HendricksonC.L.MarshallA.G., “Broadband Phase Correction of FT-ICR Mass Spectra via Simultaneous Excitation and Dectection”, Anal. Chem.76, 5756–5761 (2004). doi: 10.1021/ac049733i
18.
PurcellJ.M.HendricksonC.L.RodgersR.P.MarshallA.G., “Atmospheric Pressure Photoionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Complex Mixture Analysis”, Anal. Chem.78, 5906–5912 (2006). doi: 10.1021/ac060754h
19.
YanofskyC.M.BellA.W.LesimpleS.MoralesF.LamT.-K.T.BlakneyG.T.MarshallA.G.CarrilloB.LekporK.BoismenuD.KearneyR.E., “Multicomponent Internal Recalibration of an LC-FTICR-MS Analysis of a Partially Characterized Complex Peptide Mixture: Systematic and Random Errors”, Anal. Chem.77, 7246–7254 (2005). doi: 10.1021/ac050640q
20.
MarshallA.G.GuanS., “Advantages of High Magnetic Field for Fourier Transform Ion Cyclotron Resonance Mass Spectrometry”, Rapid Commun. Mass Spectrom.10, 1819–1823 (1996). doi: 10.1002/(SICI)1097-0231(199611)10:14<1819::AID-RCM686>3.0.CO;2-Z
