Abstract
Multiphoton ionization exhibits a number of specific features that make it a unique ionization technique for analytical and scientific mass spectrometry. Among these is the possibility of selectively ionizing certain pre-selected compounds out of complex mixtures with high efficiency while suppressing unwanted substances, a feature that can even be used to distinguish between isomers. Other interesting aspects include the ability to control the degree of fragmentation through the laser intensity and to ionize even large molecules intact especially when the ionization is induced by very short laser pulses. In this account the basic principles of the technique as well as the experimental requirements are discussed and some typical applications are demonstrated.
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