The control and transmission of ions or small charged droplets in the intermediate to high-pressure regime is of primary importance in areas such as atmospheric pressure ionisation. Where small apertures separate differentially pumped vacuum regions in the inlet systems to mass spectrometers, a large proportion of the available ion current is lost to the surrounding electrode structures. A new ion-optical device, named the ion conveyor, incorporating electrodynamic focusing and conveying of charged entities is described. Results from ion-optical simulations are presented demonstrating the performance of the device in various operating modes and electrode configurations.
YamashitaM. and FennJ.B., “Electrospray Ionization Mass Spectrometry Electrospray Ion Source. Another Variation on the Free-Jet Theme”, J. Phys. Chem.88, 4451 (1984).
2.
WhitehouseC.M.DreyerR.N.YamashitaM. and FennJ.B., “Electrospray Interface for Liquid Chromatographs and Mass Spectrometers”, Anal. Chem.57, 675 (1985).
3.
MannM.MengC.K.WongS.F.WhitehouseC.M. and FennJ.B., “Electrospray Ionization for Mass Spectrometry of Large Biomolecules”, Science246, 64 (1989).
4.
HuntS.M.SheilM.M.BelovM. and DerrickP.J., “Probing the Effects of Cone Potential in the Electrospray Ion Source: Consequences for the Determination of Molecular Weight Distributions of Synthetic Polymers”, Anal. Chem.70, 1812 (1998).
5.
ColeR.B., Electrospray Ionisation Mass Spectrometry: Fundamentals, Instrumentation & Applications.Wiley, New York (1997).
6.
ZhangY., Development of Electrospray Ionization of Biomolecules on a Magnetic Sector Mass Spectrometer, PhD thesis, University of Warwick, UK (2002).
7.
ShafferS.A.TangK.AndersonG.A.PriorD.C.UdsethH.R. and SmithR.D., “A Novel Ion Funnel for Focusing Ions at Elevated Pressure Using Electrospray Ionization Mass Spectrometry”, Rapid Commun. Mass Spectrom.11, 1813 (1997).
8.
ShafferS.A.PriorD.C.AndersonG.A.UdsethH.R. and SmithR.D., “An Ion Funnel Interface for Improved Ion Focusing and Sensitivity Using Electrospray Ionization Mass Spectrometry”, Anal. Chem.70, 4111 (1998).
9.
PaulW. and SteinwedelH, “A new mass spectrometer without magnetic field”, Z. Naturforch.8a, 448–450 (1953).
10.
KimT.TolmachevA.V.HarkewiczR.PriorD.C.AndersonG.A.UdsethH.R. and SmithR.D., “Design and Implementation of a New Electrodynamic Ion Funnel”, Anal. Chem.72, 2247 (2000).
11.
BelovM.E.GorshkovM.V.UdsethH.R.AndersonG.A. and SmithR.D., “Zeptomole-Sensitivity Electrospray Ionisation – Fourier Transform Ion Cyclotron Resonance Mass Spectrometry of Proteins”, Anal. Chem.72, 2271 (2000).
12.
DahlD.A., “SIMION 3D Version 6.0”, Proceedings of the 43rd ASMS Conference on Mass Spectrometry and Allied Topics, Atlanta, Georgia, p. 717 (1995).
