A concept of an “ideal” orthogonal-injection time-of-flight (O-TOF) mass spectrometer is proposed and a new high-resolution O-TOF mass spectrometer with an electrospray ion source and a molecule-ion reactor is described. The instrument design was optimized for high resolution and sensitivity using the concept of an ideal O-TOF mass spectrometer. A mass resolving power of about 20,000 (full width at half maximum) and a mass measurement accuracy in the 10 ppm range is demonstrated.
O'HalloranG.J.FlueggeR.A.BettsJ.F.EverettW.J., Technical Report prepared by the Bendix Corporation Research Laboratories Division, Southfield (Contract Nos AF33(616)-8374 and AF33(657)-11018, A.F. Materials Laboratory Research and Technology Division, Air Force Systems Command) (1964).
KrutchinskyA.N.LobodaA.V.SpicerV.L.DworschakR.EnsW.StandingK.G., Rapid Commun. Mass Spectrom.12, 508 (1998).
8.
MyersD.P.LiG.MahoneyP.P.HieftjeG.M., J. Am. Soc. Mass Spectrom.6, 400 (1995).
9.
SturgeonR.E.LamJ.W.H.SaintA., J. Anal. Atomic Spectrom.15, 607 (2000).
10.
MorrisH.R.PaxtonT.DellA.LanghorneJ.BergM.BordoliR.S.HoyesJ.BatemanR.H., Rapid Commun. Mass Spectrom.10, 889 (1996).
11.
GuilhausM.SelbyD.MlynskiV., Mass Spectrom. Rev.19, 65 (2000).
12.
DodonovA.F.ChernushevichI.V.LaikoV.V., in Time-of-flight Mass Spectrometry, Ed by CotterR.J., ACS Symposium Series, American Chemical Society, Washington, DC, p. 108 (1994).
13.
(a) DodonovA.KozlovskiV.LobodaA.RaznikovV.TolmachevA.AndressenM.HorwathT.KraftA.WollnikH., 14th International Mass Spectrometry Conference (Advances in Mass Spectrometry, Volume 14), abstract B04 WEPO021. Elsevier Science, Amsterdam (1997); (b) DodonovA.KozlovskiV.LobodaA.RaznikovV.TolmachevA.AndressenM.HorwathT.KraftA.WollnikH., 45th American Society of Mass Spectrometry Conference (1997); (c) DodonovA.LobodaA.KozlovskiV.RaznikovV.SoulimenkovI.TolmachevA.ZhenZ.KholomeevA.HorwathT.WollnikH., 47th American Society of Mass Spectrometry Conference (1999).
14.
DodonovA.F.KozlovskiV.I.LobodaA.V.RaznikovV.V.SulimenkovI.V.TolmachevA.V.KraftA.WollnikH., Rapid Commun. Mass Spectrom.11, 1649 (1997).
15.
LobodaA.V.KozlovskyV.I.ShardakovaE.V.TolmachevA.V.SulimenkovI.V.DodonovA.F.WollnikH., Rapid Commun. Mass Spectrom.12, 45 (1998).
16.
LaikoV.V.DodonovA.F., Rapid Commun. Mass Spectrom.8, 720 (1994).
17.
SteinR., Int. J. Mass Spectrom. Ion Processes132, 29 (1994).
