Abstract
The first examples of molecular complexes of a substituted β-cyclodextrin, amino (6-monodeoxy-6-mono)-β-cyclodextrin (β-CDNH2), with several drugs and amino acids are examined using electrospray ionization mass spectrometry. The analysis of samples which contained β-CDNH2 with cis-2-(4-methoxyphenyl)-3,4-dimethyl 5-phenyloxazolidine (an oxazolidine prod rug of (1R,2S)-(–)-ephedrine), dacarbazine, ibuprofen, terbutaline, fenoterol, amphetamine, methylphenidate, glyburide, tyrosine, tryptophan or phenylalanine are discussed. Control experiments and observation of “false positives” are also presented.
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