Abstract
The fragmentation mechanism of cis/trans-rose oxide (1,2) in mass spectrometry is investigated using specifically deuterium labeled isotopomers. The main fragmentation pathway is not initiated by the loss of the 4-methyl group as previously assumed. The labeling experiments are in agreement with a fragmentation mechanism which includes a hydrogen rearrangement of H-2 and the loss of one of the methyl groups of the isopropylidene substituent.
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