A Tribute to the Scientific Career of Dr Andries Bruins

Sparks J.B. , Histomap of World History. Rand McNally. Available from the John Sparks Trust Fund by contacting his granddaughter Jackie Glanz at jacquieglanz@yahoo.com

Diamond J. , Guns, Germs, and Steel. W.W. Norton & Co., New York, USA, (1999).

Tal'rose V.L. Karpov G.V. Gorodetskii I.G. Skurat V.E. , “Capillary system for the introduction of liquid mixtures into an analytical mass-spectrometer”, Russ. J. Phys. Chem. 42(12), 1658 (1968).

Dole M. Mack L.L. Hines R.L. Mobley R.C. Ferguson L.D. Alice M.B. , “Molecular beams of macroions”, J. Phys. Chem. Phys. 49(1), 2240–2249 (1968). doi: 10.1063/1.1670391

Baldwin M.S. McLafferty F.W. , “The direct introduction of liquid solutions into a chemical ionization mass spectrometer”, Org. Mass Spectrom. 7, 1111–1112 (1973). doi: 10.1002/oms.1210070913

Carroll C.I. Dzidic R.N. Stillwell R.N. Horning M.G. Horning F.C. , “Subpicogram detection system for gas phase analysis based in atmospheric pressure ionization mass spectrometry”, Anal. Chem. 46(6), 706 (1974). doi: 10.1021/ac60342a009

Bruins A.P. Nibbering N.M.M. de Boer Th.J. , “A marked difference between the decomposing (M-H)⁺ ions from benzyl amine and p-aminotoluene, in the light of benzyl versus tropylium ion structures”, Tetrahedron Lett. 13, 1109 (1972). doi: 10.1016/S0040-4039(01)84521-4

Bruins A.P. Nibbering N.M.M. , “On the loss of a benzyl radical from the molecular ion of alpha, omegadibenzyloxyalkanes; evidence for a benzyl cation transfer in an SNi-type reaction, revealed by a simultaneous D- and 18O-labelling”, Tetrahedron 30, 493 (1974). doi: 10.1016/S0040-4020(01)97030-9

Bruins A.P. Nibbering N.M.M. : “An ICR study on benzyl cation transfer reactions and the nucleophylic attack of amines on the C₇H₇⁺ ion from benzyl methyl ether”, Tetrahedron Lett. 15, 2680 (1974). doi: 10.1016/S0040-4039(01)92326-3

Bruins A.P. Nibbering N.M.M. , “An ICR study on benzoylation reactions in the gas phase”, Tetrahedron Lett. 16, 4491 (1975). doi: 10.1016/S0040-4039(00)91101-8

Bruins A.P. Nibbering N.M.M. , “Chain length effects in the competition between intramolecular hydrogen migrations in the molecular ions of alpha-benzylaminoomega-benzyloxyalkanes as studied by deuterium labeling”, Org. Mass Spectrom. 11, 271 (1976). doi: 10.1002/oms.1210110307

Bruins A.P. Nibbering N.M.M. , “Hydrogen scrambling in the long-lived protonated benzene ion generated from benzyl amine in the ICR spectrometer”, Org. Mass Spectrom. 11, 950 (1976). doi: 10.1002/oms.1210110906

Bruins A.P. Jennings K.R. Evans S. , “The observation of metastable transitions in a double focusing mass spectrometer using a linked scan of the electric sector and magnetic sector fields”, Int. J. Mass Spectrom. Ion Phys. 26, 395 (1978). doi: 10.1016/0020-7381(78)80058-8

Boyd R.K. Beynon J.H. , “Scanning sector mass spectrometers to observe the fragments of metastable ions”, Org. Mass Spectrom. 12(3), 163 (1977). doi: 10.1002/oms.1210120311

Henion J.D. , “Drug analysis by continuously monitored liquid chromatography/mass spectrometry with a quadrupole mass spectrometer”, Anal. Chem. 50(12), 1887 (1978). doi: 10.1021/ac50034a029

McFadden W.H. Schwartz H.L. Evans S. , “Direct analysis of liquid chromatographic effluents”, J. Chromatogr. 122, 386–296 (1976). doi: 10.1016/S0021-9673(00)82261-X

Bruins A.P. , “Negative ion chemical ionization mass spectrometry in the determination of components in essential oils”, Anal. Chem. 51, 967 (1979). doi: 10.1021/ac50043a043

Bruins A.P. , “A simple and inexpensive modification of a Finnigan 3300 quadrupole mass spectrometer for negative ion detection”, Biomed. Mass Spectrom. 10, 46 (1983). doi: 10.1002/bms.1200100109

Bruins A.P. , “Probe for the introduction of nonvolatile samples into a chemical ionization source by thermal desorption from a platinum wire”, Anal. Chem. 52, 605 (1980). doi: 10.1021/ac50053a063

Bruins A.P. , “Negative ion chemical ionization mass spectrometry of steroid glycosides by “in beam” sample introduction on glass rods and thermal desorption from a platinum wire”, Adv. Mass Spectrom. 8, 246 (1980).

Bruins A.P. , “Negative ion desorption chemical ionization mass spectrometry of some underivatized glucuronides”, Biomed. Mass Spectrom. 8, 31 (1981). doi: 10.1002/bms.1200080108

Thomson B.A. Iribarne J.V. , “The fate of electrical charges in evaporating cloud droplets”, Rev. Geophys. Space Phys. 16(3), 431–434 (1978). doi: 10.1029/RG016i003p00431

Thomson B.A. Irabarne J.V. , “Field induced ion evaporation from liquid surfaces at atmospheric pressure”, J. Chem. Phys. 71(11), 4451–4463 (1979). doi: 10.1063/1.438198

Thomson B.A. Irabarne J.V. Dziedzic P.J. , “Liquid ion evaporation/mass spectrometry/mass spectrometry for the detection of polar and labile molecules”, Anal. Chem. 54, 2219–2224 (1982). doi: 10.1021/ac00250a020

Bruins A.P. Drenth B.F.H. , “Experiments with the combination of a micro liquid chromatograph and a chemical ionization quadrupole mass spectrometer, using a capillary interface for direct liquid introduction. Some theoretical considerations concerning the evaporation of liquids from capillaries into vacuum”, J. Chromatogr. 271, 71 (1983). doi: 10.1016/S0021-9673(00)80200-9

Blakley C.R. Carmody J.J. Vestal M.L. , “Liquid chromatograph-mass spectrometer for analysis of nonvolatile samples”, Anal. Chem. 52, 1636 (1980). doi: 10.1021/ac50061a025

Willoughby R.C. Browner R.F. , “Monodisperse aerosol generation interface for combining liquid chromatography with mass spectrometry”, Anal. Chem. 56, 2626–2631 (1984). doi: 10.1021/ac00278a003

Barber M. Bordoli R.S. Sedgwick R.D. Tyler A.N. , “Fast atom bombardment of solids (FAB)—a new ion source for mass spectrometry”, J. Chem. Soc. Chem. Commun. 325–327 (1981). doi: 10.1039/c39810000325

Ito Y. Takeuchi T. Ishii D. Goto M. , “Direct coupling of micro-high performance liquid chromatography with fast atom bombardment mass spectrometry”, J. Chromatogr. 346, 161–166 (1985). doi: 10.1016/S0021-9673(00)90502-8

Caproli R.M. Fan T. Cottrell J.S. , “Continuous-flow sample probe for fast atom bombardment mass spectrometry”, Anal. Chem. 58, 2949–2954 (1986). doi: 10.1021/ac00127a012

Henion J.D. Thomson B.A. Dawson P.H. , “Determination of sulfa drugs in biological fluids by liquid chromatography/mass spectrometry/mass spectrometry”, Anal. Chem. 54, 451–456 (1982). doi: 10.1021/ac00240a023

Covey T.R. Lee E.D. Henion J.D. , “High-speed liquid chromatography/tandem mass spectrometry for the determination of drugs in biological samples”, Anal. Chem. 58, 2453–2460 (1986). doi: 10.1021/ac00125a022

Hopfgartner G. Bourgogne E. , “Quantitative high-throughput analysis of drugs in biological matrices by mass spectrometry”, Mass Spectrom. Rev. 22, 195–214 (2003). doi: 10.1002/mas.10050

Lee M.S. , Integrated Strategies for Drug Discovery using Mass Spectrometry. John Wiley & Sons, Inc. New York, USA, 568 pp. (2005). doi: 10.1002/0471721034

Lee M.S. , LC/MS Applications in Drug Development. John Wiley & Sons, Inc. New York, USA, 256 pp. (2002).

French J.B. Reid N.M. Buckley J.A. , “Apparatus for analyzing trace components in air, US Patent 4,023,398, (1977).

Yamashita M. Fenn J.B. , “Electrospray ion source. Another variation on the free-jet theme”, J. Phys. Chem. 88, 4451–4459 (1984). doi: 10.1021/j150664a002

Alexandrov M.L. Gall L.N. Krasnov N.V. Nikolaev V.I. Pavlenko V.A. Shkurov V.A. , “Extraction of ions from solution under atmospheric pressure as a method for mass spectrometric analysis of bioorganic compounds”, Dolk. Adak. Nauk SSSR 277, 379–383 (1984). English translation re-published in Rapid Commun. Mass Spectrom. 22, 267–270 (2008).

Bruins A.P. Covey T.R. Henion J.D. , “Ion spray interface for combined liquid chromatography/atmospheric pressure ionization mass spectrometry”, Anal. Chem. 59, 2642–2646 (1987). doi: 10.1021/ac00149a003

Bruins A.P. , “Mass spectrometry with ion sources operating at atmospheric pressure”, Mass Spectrom. Rev. 10, 53–77 (1991). doi: 10.1002/mas.1280100104

Raffaelli A. Bruins A.P. , “Factors affecting the ionization efficiency of quaternary ammonium compounds in electrospray/ionspray mass spectrometry”, Rapid Commun. Mass Spectrom. 5, 269–275 (1991). doi: 10.1002/rcm.1290050605

Kostiainen R. Bruins A.P. , “Effect of multiple sprayers on dynamic range and flow rate limitations in electrospray and ionspray mass spectrometry”, Rapid Commun. Mass Spectrom. 8, 549–558 (1994). doi: 10.1002/rcm.1290080712

Kostiainen R. Bruins A.P. , “Effect of solvent on dynamic range and sensitivity in pneumatically assisted electrospray (ionspray) mass spectrometry”, Rapid Commun. Mass Spectrom. 10, 1393–1399 (1996). doi: 10.1002/(SICI)1097-0231(199608)10:11<1393::AID-RCM654>3.0.CO;2-V

Zook D.R. Bruins A.P. , “On cluster ions, ion transmission, and linear dynamic range limitations in electrospray (ionspray) mass spectrometry”, Int. J. Mass Spectrom. Ion Processes 162, 129–147 (1997). doi: 10.1016/S0168-1176(96)04511-9

Fenn J.B. Mann M. Meng C.K. Wong S.F. Whitehouse C.M. , “Electrospray ionization for mass spectrometry of large biomolecules”, Science 246, 64–70, (1989). doi: 10.1126/science.2675315

Covey T.R. Bonner R.F. Shushan B.I. Henion J. , “The determination of protein, oligonucleotide, and peptide molecular weights”, Rapid Commun. Mass Spectrom. 2(11), 249–256 (1988). doi: 10.1002/rcm.1290021111

Wilm M. Mann M. , “Electrospray and Taylor–Cone theory. Dole's beam of macromolecules at last?” Int. J. Mass Spectrom. Ion Processes 136, 167–180 (1994). doi: 10.1016/0168-1176(94)04024-9

Valaskovic G.A. McLafferty F.W. , “Long-lived metallized tips for nanoliter electrospray mass spectrometry”, J. Am. Soc. Mass Spectrom. 7, 1270–1272 (1996). doi: 10.1016/S1044-0305(96)00152-3

Schultz G.A. Corso T.N. Prosser S.J. Zhang S. , “A fully integrated monolithic microchip electrospray device for mass spectrometry,” Anal. Chem. 72, 4058–4063 (2000). doi: 10.1021/ac000325y

Covey T.R. , “Development of gas dynamic focusing for pneumatically assisted electrospray (ionspray) sample introduction”, presented at the 42^nd American Society for Mass Spectrometry Conference, Chicago. USA (1994).

Covey T.R. , “Analytical characterisitics of the electrospray ionization process”, in Biochemical and Biotechnological Applications of Electrospray Ionization Mass Spectrometry—ACS Symposium Series 619, Chapter 2, Ed by Snyder A.P. , American Chemical Society, Washington, DC, USA (1995).

Covey T.R. , “Pneumatically assisted electrospray”, in Encyclopedia of Mass Spectrometry, Ed by Gross M. Caprioli R. ,. Volume 6, Ionization Methods. Elsevier Ltd, Oxford, UK, pp. 426–435 (2007).

Wang T. Zeng L. Cohen J. Kassel D.B. , “A multiple electrospray interface for parallel mass spectrometric analyses of compound libraries”, Comb. Chem. High T. Scr. 2, 327–334 (1999).

Schneider B.B. Covey T.R. , “Multiple sprayers in electrospray ionization”, in Encyclopedia of Mass Spectrometry, Ed by Gross M. Caprioli R. , Volume 6, Ionization Methods. Elsevier Ltd, Oxford, UK, pp. 456–467 (2007).

Robb D.B. Covey T.R. Bruins A.P. , “Atmospheric pressure photoionization: An ionization method for liquid chromatography/mass spectrometry”, Anal. Chem. 72, 3653–3659, (2000). doi: 10.1021/ac0001636

Kauppila T.J. Kostiainen R. Bruins A.P. , “Anisole, a new dopant for atmospheric pressure photoionization mass spectrometry of low proton affinity, low ionization energy compounds”, Rapid Commun. Mass Spectrom. 18, 808–815 (2004). doi: 10.1002/rcm.1408

Van Berkel G.J. Pasilis S.P. Ovchinnikova O. , “Established and emerging atmospheric pressure surface sampling/ionization techniques for mass spectrometry”, J. Mass Spectrom. 43, 1161–1180 (2008). doi: 10.1002/jms.1440

Kertesz V. Ford M.J. Van Berkel G.J. , “Automation of a surface sampling probe/electrospray mass spectrometry system”, Anal. Chem. 77(22), 7183–7189 (2005). doi: 10.1021/ac0510742

Cooks R.G. Ouyang Z. Takats Z. Wiseman J.M. , “Ambient mass spectrometry”, Science 311, 1566–1570 (2006). doi: 10.1126/science.1119426

Cody R.B. Laramee J.A. , “Versatile new ion source for the analysis of materials in open air under ambient conditions”, Anal. Chem. 77, 2297–2302 (2005). doi: 10.1021/ac050162j

McEwen C.N. McKay R.G. Larsen B.S. , “The analysis of solids, liquids, and biological tissues using solids probe introduction at atmospheric pressure on commercial LC/MS instrumentation”, Anal. Chem. 77, 7826–7831, (2005). doi: 10.1021/ac051470k

Picard P. Carrier V. Paquin R. , “Atmospheric pressure Laser Diode Thermal Desorption Mass Spectrometry: A new high performance ionization source”, Presented at the 54th American Society Mass Spectrometry Conference, San Antonio, USA (2005).

Getek T.A. Korfmacher W.A. McRae T.A. Hinson J.A. , “Utility of solution electrochemistry mass spectrometry for investigating the formation and detection of biologically important conjugates of acetaminophen”, J. Chromatogr. 474, 245–256 (1989). doi: 10.1016/S0021-9673(01)93919-6

Guo X. Bruins A.P. Covey T.R. , “Characterization of typical chemical backround interferences in atmospheric pressure ionization liquid chromatography-mass spectrometry”, Rapid Commun. Mass Spectrom. 20, 3145–3150 (2006). doi: 10.1002/rcm.2715

Guo X. Bruins A.P. Covey T.R. , “Method to reduce chemical background Interference in atmospheric pressure ionization liquid chromatography-mass spectrometry using exclusive reactions with the chemical reagent dimethyl disulfide”, Anal. Chem. 79, 4013–4021 (2007). doi: 10.1021/ac062365t

Jurva U. Wikström H.V. Bruins A.P. : “In vitro mimicry of metabolic oxidation reactions by electrochemistry/mass spectrometry”, Rapid Commun. Mass Spectrom. 14, 529–533 (2000). doi: 10.1002/(SICI)1097-0231(20000331)14:6<529::AID-RCM904>3.0.CO;2-H

Permentier H.P. Bruins A.P. , “Electrochemical oxidation and cleavage of proteins with on-line mass spectrometric detection: Development of an instrumental alternative to enzymatic protein digestion”, J. Am. Soc. Mass Spectrom. 15, 1707–1716 (2004). doi: 10.1016/j.jasms.2004.09.003