A preliminary investigation is reported into the diffusion of a quinine derivative through composite membranes obtained by the deposition of phospholipid Langmuir-Blodgett films on to porous nylon supports. The results suggest that the thin organic layers probably collapse into the pores in the membrane rather than bridge them. It is found that the diffusion of the drug can be influenced by the application of an electric field.
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References
1.
LangerR.New methods of drug delivery. Science, 1990, 249, 1527–1533.
2.
KokufataE.ZhangY. Q.TanakaT.Saccharide-sensitive phase transition of a lectin-loaded gel. Nature, 1991, 351, 302–304.
3.
KwonI. C.BaeY. H.KimS. W.Electrically erodible polymer gel for controlled release of drugs. Nature, 1991, 354, 291–293.
4.
RobertsG. G.Langmuir-Blodgett films, 1990 (Plenum Press, New York).
5.
ColemanL. B.FiskeT. G.StroeveP.CoelhoM. A. N.DongS.RingsdorfH.SchneiderJ.Effects of heating on the molecular orientation of polymeric liquids. Thin Solid Films, 1989, 178, 227–232.
6.
StroeveP.CoelhoM. A. N.DongS.LamP.ColemanL. B.FiskeT. G.RingsdorfH.SchneiderJ.Gas transfer in supported Langmuir-Blodgett films on polymeric lipids. Thin Solid Films, 1989, 180, 241–248.
7.
BruinsmaP. J.SpoonerG. J. R.ColemanL. B.KorenR.SturessonC.StroeveP.Selectivity of toxic and acid gases over methane and nitrogen in Langmuir-Blodgett films. Thin Solid Films, 1992, 210/211, 440–442.
8.
CuiD. F.HowarthV. A.PettyM. C.AncelinH.YarwoodJ.The deposition and characterization of phosphatidic acid Langmuir-Blodgett films. Thin Solid Films, 1990, 192, 391–396.
9.
RobertsonR. N.The lively membranes, 1983 (Cambridge University Press, Cambridge).
10.
KunitakeT.HigashiN.KunitakeM.FukushigeY.Permeation of aqueous KBr through Langmuir-Blodgett films of singly and doubly polymeric monolayers. Macromolecules, 1989, 22, 485–487.
11.
GainesG. L.Jr.Insoluble monolayers at liquid-gas interfaces, 1966 (Wiley-Interscience, New York).
