A combined theoretical and experimental investigation is reported with respect to the influence of mechanical loading on loosening at the cement bone interface of knee prostheses with intermedullary stems. The in vitro experiments have been performed under cyclic loading conditions with the tibial part of a Shiers knee prosthesis implanted in fresh cadaver tibiae.
The experimental results indicate an unfavourable effect of peak loading (as occurring in walking up stairs) on loosening as compared with loading due to normal walking conditions.
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