A burn wound covering based on an acrylonitrile-dimethylaminoethyl methacrylate copolymer membrane is described. The requirements for a burn wound covering are discussed and a particular requirement, that of adequate water vapour permeability, is considered in detail. The effects on membrane water vapour permeability of contacting the membrane with ethylene oxide gas and of incorporating plasticizers are reported.
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References
1.
ASTM Method E96–66 (1972) Standard methods of test for water vapour transmission of materials in sheet form.
2.
BatstoneG. F.AlbertiK. G. M. M.HinksL.SmytheP.LaingJ. E.WardC. M.ElyD. W.BloomS. R. (1976) Metabolic studies in subjects following thermal injury. Burns, 2, 207.
3.
Battelle Institute, Frankfurt (1976) Verwendung einer Membran für medizinisch-biologische Zwecke. Offenlegungschrift 2508416, W. Germany Patent Office.
4.
CourtneyJ. M. (1969) New synthetic polymer membranes for extra-corporeal haemodialysis. PhD Thesis, University of Strathclyde.
5.
CourtneyJ. M.GaylorJ. D. S.MartinI.LindsayR. M. (in press) Acrylonitrile copolymer membranes: Transport charateristics and blood compatibility. In Technical aspects of Renal Dialysis. Ed. FrostT., Pitman.
6.
CourtneyJ. M.GilchristT. (1975) Chemical modification of acrylonitrile copolymers: Reaction of cationic copolymers with ethylene oxide. J. Appl. Polymer Sci., 19, 1503.
7.
CourtneyJ. M.GilchristT.MuirW. M. (1975) A method of modifying the properties of a polymer. Brit. Pat. 1,411,843.
8.
CourtneyJ. M.GilchristT.ParkG. B. (1976) Wound coverings. Brit. Pat. Appln8200/76.
9.
CourtneyJ. M.HoodR. G. (1976) The design of a gas reactor for modifying and controlling the properties of polymers. Engineering Designer, 2 (4), 13.
10.
CourtneyJ. M.ParkG. B.FairweatherI. A.LindsayR. M. (1976) Polymer structure and blood compatability evaluation—application of an acrylonitrile copolymer. Biomat., Med. Dev., Art. Org., 4, 263.
11.
FalbR. D. (1975) Surface-bonded heparin. In Polymers in Medicine and Surgery. Eds. KronenthalR.OserZ.MartinE., p. 77, Plenum Press.
12.
GrayR. A. (1970) Vinyl copolymer membranes for haemodialysis. PhD Thesis, University of Strathclyde.
13.
IdezukiY.WatanabeH.HagiwaraM.KanasugiK.MoriY.NagaokaS.HagioM.YamamotoK.TanzawaH. (1975) Mechanism of antithrombogenicity of a new heparinised hydrophilic polymer: Chronic in vivo studies and clinical application. Trans. Amer. Soc. Artif. Int. Organs.21, 436.
14.
JamesJ. H.WatsonA. C. H. (1975) Use of Op-site, a vapour permeable dressing for skin graft donor sites. Brit. J. Plastic Surg., 28, 107.
15.
LamkeL-O. (1971) The influence of different ‘skin grafts’ on the evaporative water loss from burns. Scand. J. Plast. Reconstr. Surg., 5, 82.
16.
LendrumJ.Bowen-JonesE. (1976) A new dressing for burns—enclosure in a plasticized polyvinyl chloride sheet. Burns, 2, 86.
17.
LymanD. J.BrashJ. L.HamiltonR. D.BraumanS. K.FritzingerB. K.KleinK. G.LooB. H. (1969) U.S. Nat. Tech, Inform. Serv., P.B. Report No. 188031.
18.
ManN-K.TerlainB.ParisJ.WernerG.SausseA.Funck-BrentanoJ. L. (1973) An approach to ‘middle molecules’ identification in artificial kidney dialysate with reference to neuropathy prevention. Trans. Amer. Soc. Artif. Int. Organs, 19, 320.
19.
McKnightJ. J.GuldalianJ. (1974) Laminated collagen film dressing. U.S. Patent 3,800,792.
20.
MartinI. (1974) Vinyl copolymer evaluation for medical and industrial processes. PhD Thesis, University of Strathclyde.
21.
MaxwellJ.KleemanM. (1962) In Clinical Disorders of Fluid and Electrolyte Metabolism.McGraw-Hill, New York.
22.
MuirW. M.CourtneyJ. M.GrayR. A. (1972) Haemodialysis membranes. In Developments in Biomedical Engineering. Ed. BlackM. M., p. 92, Sussex University Press.
23.
MuirW. M.CourtneyJ. M.GrayR. A.RitchieP. D. (1971) Perm-selective dialysis membranes. I. Films based on dimethylaminoethyl methacrylate copolymers. J. Biomed. Mater. Res., 5, 415.
24.
MuirW. M.CourtneyJ. M.GrayR. A. (1970) Diffusion transport mechanisms in new synthetic perm-selective dialysis membranes. Medical and Biological Engineering, 8, 445.
25.
MuirW. M.GrayR. A.CourtneyJ. M.RitchieP. D. (1973) Perm-selective dialysis membranes. II. Films based on acrylic-n-butyl methacrylate copolymers—a critical comparison with cellulose films. J. Biomed. Mater. Res., 7, 37.
26.
ParkG. B.MollisonD. S.CourtneyJ. M.KenediR. M. (to be published) In vitro bacteriological study on novel polymeric burn wound coverings.
27.
ParkG. B.MollisonD. S.CourtneyJ. M. (1976) Antibacterial effects of sulphonamide impregnated membranes. IRCS Med. Sci., 4, 324.
28.
ParkG. B.MollisonD. S.CourtneyJ. M.GaylorJ. D. S.McNairA.(in press) Polymeric films as burn wound coverings. Proc. Europ. Soc. Artif. Organs, 3.
29.
Rhone-PoulencS. A. (1973) Dialysis and ultrafiltration of a liquid. Brit. Pat. 1,327,990.
30.
SalyerI. O.BallG. L.BeemsterboerG. L.LeonardR. L.MerrillJ. P.HampersC. L.LowrieE. G. (1972) The Monsanto polyacrylonitrile hollow-fibre artificial kidney. J. Biomed. Mater. Res., 6, 59.
31.
SchwartzI. L. (1960) In Mineral Metabolism, Vol. 1, Part A, Academic Press, New York.
32.
TownsendP. L. G. (1976) The quest for a cheap and painless donor site dressing. Burns, 2, 82.
