Neutralizing antibodies to interferon-beta may persist after cessation of therapy: what impact could they have?

Abstract

Get full access to this article

View all access options for this article.

References

Sorensen PS , Koch-Henriksen N , Ravnborg M , Frederiksen JL , Jensen K , Heltberg A et al on behalf of the Danish Multiple Sclerosis Study Group . Immunomodulatory treatment of multiple sclerosis in Denmark: a prospective nationwide survey . Mult Scler 2006; 12: 253-264 .

Sorensen PS , Ross C , Clemmesen KM , Bendtzen K , Frederiksen JL , Jensen K et al ; Danish Multiple Sclerosis Study Group . Clinical importance of neutralising antibodies against interferon beta in patients with relapsing-remitting multiple sclerosis . Lancet 2003; 362: 1184-1191 .

Petersen B , Bendtzen K , Koch-Henriksen N , Ravn-borg M , Ross C , Sorensen PS on behalf of The Danish Multiple Sclerosis Group . Persistence of neutralizing antibodies after discontinuation of IFN-b therapy in patients with relapsing-remitting multiple sclerosis . Mult Scler 2006; 12: 247-252 .

Sorensen PS , Koch-Henriksen N , Ross C , Clemmesen KM , Bendtzen K; Danish Multiple Sclerosis Study Group . Appearance and disappearance of neutralizing antibodies during interferon-beta therapy . Neurology 2005; 65: 33-39 .

Hermeling S , Jiskoot W , Crommelin D , Bornaes C , Schellekens H. Development of a transgenic mouse model immune tolerant for human interferon beta . Pharm Res 2005; 22: 847-851 .

Teige I , Treschow A , Teige A , Mattsson R , Navikas V , Leanderson T et al. IFN-beta gene deletion leads to augmented and chronic demyelinating experimental autoimmune encephalomyelitis . J Immunol 2003; 170: 4776-4784 .

Erlandsson L , Blumenthal R , Eloranta ML , Engel H , Alm G , Weiss S et al. Interferon-beta is required for interferon-alpha production in mouse fibroblasts . Curr Biol 1998; 8: 223-226 .