Hereditary Melkersson-Rosenthal syndrome and multiple sclerosis

Abstract

The revision of MEDLINE from 1966 to 2003 did not report any association between multiple sclerosis (MS) and Melkersson—Rosenthal syndrome (MRS). This is a case report of a 51-year-old woman, with history of four recurrent Bell’s palsies. In 1999 she developed a right facial paralysis due to a supranuclear pyramidal lesion with right monoparesis. The family history showed five relatives with recurrent Bell’s paralysis and plicata tongue. Physical examination: right Bell’s paralysis, left supranuclear facial paralysis, furrowed tongue, right hemiparesis with pallor of the optic disks. Brain magnetic resonance imaging (MRI) demonstrated the typical lesions of MS and CSF oligoclonal bands. This is the first observation of a patient with hereditary MRS and MS. The link between both diseases is discussed.

Keywords

Melkersson-Rosenthal syndrome multiple sclerosis multiple sclerosis relapsing-remitting

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References

González Compta X , González Ruperez J , Rivas Lacarte P , García García E , Javaloyas de Morlius M. Melkersson-Rosenthal syndrome: diagnostic considerations . Revista Clinica Española 2001; 201: 223-225 .

McDonald WI , Compston A , Edan G , Goodkin D , Hartung H-P , Lublin FD et al. Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of MS . Ann Neurol 2001; 50: 121-127 .

Lublin FD , Reingold SC. Defining the clinical course of multiple sclerosis: results of an international survey . Neurology 1996; 46: 907-911 .

Goto A , Kume A , Aiba I , Yasuda T , Murakami NA. A case of typical Melkersson-Rosenthal syndrome with possible auto-somal dominant inheritance . Rinsho Shinkeigaku-Clinical Neurology 1999; 39: 20-24 .

Lim SH , Stephens P , Cao QX , Coleman S , Thomas DW. Lesions in MRS . Gut 1997; 40: 683-686 .

Ferriby D , Pertuzon B , Clarisse J , Vermersch P. Magnetic resonance imaging of the facial nerve in a case of Melkersson-Rosenthal syndrome . Revue Neurologique 1998; 154: 426-428 .

Ronnblom L , Forsum U , Evrin PE , Gillnas T , Nethander G. Intralesional T lymphocyte phenotypes and HLA-DR expression in Melkersson-Rosenthal syndrome . International Journal of Oral & Maxillofacial Surgery 1986; 15: 614-619 .

Martínez-Naves E , Victoria-Gutiérrez M , Uria DF , Lopez-Larrea C. The germline repertoire of T cell receptor b-chain genes in MS patients from Spain . J Neuroimmunol 1993; 47: 9-14 .

Cabrera-Gómez JA. La esclerosis múltiple en el Caribe. In Arriagada-Nogales ed. Esclerosis Múltiple: una mirada iberopanamericana, 1st edition. Santiago de Chile: Arrynog , 2002: 155-179.