Multiple sclerosis in women having children by multiple partners. A population-based study in Denmark

Abstract

We investigated whether having children with multiple men is a risk factor for being diagnosed with multiple sclerosis (MS). We studied a cohort of 151 328 women, of whom 64 704 had different men fathering their children and 86 624 the same partner for all births. Women were included if they had a second or higher parity child between 1973 and 1996. The follow-up for MS ended in 1997. There were a total of 213 cases of MS diagnosed during the study period. We analysed data through Poisson regression models. Women having children with different men were not at higher risk of being diagnosed with MS, with the possible exception of a short period after having a baby with a new partner. Women having children with more than one man may have a higher risk of a pregnancy accelerating the diagnosis of MS but are probably not at an overall higher risk of MS.

Keywords

multiple sclerosis longitudinal study multiple partners microchimerism

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References

Granieri E , Casetta I , Tola MR , Ferrante P. Multiple sclerosis: infectious hypothesis . Neurol Sci 2001; 22: 179-185 .

Wolfson C , Talbot P. Bacterial infection as a cause of multiple sclerosis . Lancet 2002; 360: 352-353 .

Moore FG , Wolfson C. Human herpes virus 6 and multiple sclerosis . Acta Neurol Scand 2002; 106: 63-83 .

Hawkes CH.

Is multiple sclerosis a sexually transmitted infection?

J Neurol Neurosurg Psychiatry 2002; 73: 439-443 .

Munger KL , Peeling RW , Hernan MA , Chasan-Taber L , Olek MJ , Hankinson SE et al. Infection with Chlamydia pneumoniae and risk of multiple sclerosis . Epidemiology 2003; 14: 141-147 .

Koch-Henriksen N. The Danish Multiple Sclerosis Registry: a 50-year follow-up . Mult Scler 1999; 5: 293-296 .

Whitacre CC , Reingold SC , O’Looney PA. A gender gap in autoimmunity . Science 1999; 283: 1277-1278 .

Whitacre CC. Sex differences in autoimmune disease . Nat Immunol 2001; 2: 777-780 .

Buyon JP. The effects of pregnancy on autoimmune diseases . J Leukoc Biol 1998; 63: 281-287 .

10.

Bianchi DW , Zickwolf GK , Weil GJ , Sylvester S , DeMaria MA. Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum . Proc Natl Acad Sci USA 1996; 93: 705-708 .

11.

Nelson JL , Furst DE , Maloney S , Gooley T , Evans PC , Smith A et al. Microchimerism and HLA-compatible relationships of pregnancy in scleroderma . Lancet 1998; 351: 559-562 .

12.

Srivatsa B , Srivatsa S , Johnson KL , Samura O , Lee SL , Bianchi DW. Microchimerism of presumed fetal origin in thyroid specimens from women: a case-control study . Lancet 2001; 358: 2034-2038 .

13.

Willer CJ , Sadovnick AD , Ebers GC. Microchimerism in autoimmunity and transplantation: potential relevance to multiple sclerosis . J Neuroimmunol 2002; 126: 126-133 .

14.

Nelson JL.

Pregnancy and microchimerism in autoimmune disease: protector or insurgent?

Arthritis Rheum 2002; 46: 291-297 .

15.

Hernan MA , Hohol MJ , Olek MJ , Spiegelman D , Ascherio A. Oral contraceptives and the incidence of multiple sclerosis . Neurology 2000; 55: 848-854 .

16.

Basso O , Christensen K , Olsen J.

Higher risk of pre-eclampsia after change of partner. An effect of longer interpregnancy intervals?

Epidemiology 2001; 12: 624-629 .

17.

Olsen J , Campi R , Frydenbeg M , Basso O , Ebbesen P. Studying health consequences of microchimerism-methodological problems in studying health effects with multiple individuals . Eur J Epidemiol 2003; 18: 623-629 .