CD8 + T cells reduce in vitro interferon-g production in Theiler’s murine encephalomyelitis virus-induced demyelinating disease model

Abstract

In the Theiler’s murine encephalomyelitis virus (TMEV)-induced demyelinating disease model for multiple sclerosis, regulatory CD8- T cells prevent demyelinating disease and reducein vivo interferon (IFN)-g production by anti-TMEV CD4- blast cells in BALB/c mice. We describe here that regulatory CD8- T cells reduce in vitro IFN-g production by lymph node cells from both TMEV and fowl gamma globulin immunized mice without affecting interleukin (IL)-4, IL-10, tumour growth factor-b or tumour necrosis factor-a production.

Keywords

autoimmune demyelination interferon-γ multiple sclerosis regulatory CD8+T cells TMEV

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