Etoposide intravenous solution is associated with leaching of diethylhexyl phthalate (DEHP) from bags and tubings made from polyvinyl chloride (PVC). Recent evidence suggests that this may be more substantial than previously found. Since DEHP is potentially hepatotoxic and carcinogenic, it is preferable to prepare and administer etopo-side bags and tubings made from non-PVC materials.
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Bagel-Boithias S, Sautou-Miranda V, Bourdeaux D, et al.Leaching of diethylhexyl phthalate from multilayer tubing into etoposide infusion solutions. Am J Health Syst Pharm2005; 62(2): 182-188.
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