Abstract
A 14-year-old girl developed maculopapular rash, myalgias, arthralgias and myocarditis with elevated anti-nuclear and anti-double-stranded DNA antibodies. She was taking minocycline for acne and all symptoms resolved when this treatment was stopped. The patient has no evidence of disease one year after onset of symptoms. Clinicians should be aware of minocycline's responsibility in inducing lupus-like disease.
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References
1.
1
Shapiro LE
,
Knowles SR
,
Shear NH
. Comparative safety of tetracycline, minocycline, and doxycycline . Arch Dermatol
1997 ; 133 : 1224 -1230 .
2.
2
Hess E
. Drug-related lupus . N Engl J Med
1988 ; 318 : 1460 -1462 .
3.
3
Knowles SR
,
Shapiro L
,
Shear NH
. Serious adverse reactions induced by minocycline . Arch Derinatol
1996 ; 132 : 934 -939 .
4.
4
Masson C
et al. Minocycline related lupus . J Rheumatol
1996 ; 23 : 2160 -2161 .
5.
5
Akin E
,
Miller LC
,
Tucker LB
. Minocycline-induced lupus in adolescents . Pediatrics
1998 ; 101 : 926 -928 .
6.
6
Gough A
et al. Minocycline induced autoimmune heptitis and systemic lupus erythematosus-like syndrome . Br M J
1996 ; 312 : 169 -172 .
7.
7
Crosson J
,
Stillman T
. Minocycline-related lupus erythematosus with associated liver disease . J Am Acad Dermatol
1997 ; 36 : 867 -868 .
8.
8
Knights SE
,
Leandro MJ
,
Khamashta MA
,
Hughes GR
. Minocycline-induced arthritis . Clin Exp Rheumatol
1998 ; 16 : 587 -590 .
9.
9
Elkayam O
et al. Clinical and immunological study of 7 patients with minocycline-induced auto-immune phenomena . Am J Med
1998 ; 105 : 484 -487 .
10.
10
Tubach F
,
Kaplan G
,
Bernbaum F
. Highly positive dsDNA antibodies in minocycline-induced lupus . Clin Exp Rheumatol
1999 ; 17 : 124 -125 .
