Signaling in human lupus T lymphocytes

Zouali M . Development of human antibody variable genes in systemic autoimmunity . Immunol Rev 1992; 128: 73–99 .

Stollar BD . Molecular analysis of anti–DNA antibodies . FASEB J 1994; 8: 337–342 .

Hahn BH . Antibodies to DNA . New Eng J Med 1998; 338: 1359–1368 .

Takeno M et al. Autoreactive T cell clones from patients with systemic lupus erythematosus support polyclonal autoantibody production . J Immunol 1997; 158: 3529–3538 .

Shi Y et al. Promiscuous presentation and recognition of nucleosomal autoepitopes in lupus: role of autoimmune T cell receptor alpha chain . J Exp Med 1998; 187: 367–378 .

Huck S , Zouali M . DNA methylation: a potential pathway to abnormal autoreative lupus B cells . Clin Immunol Immunopathol 1996; 80: 1–8 .

Sierakowski S , Kucharz EJ , Lightfoot RW , Goodwin JS . Impaired Tcell activation in patients with systemic lupus erythematosus . J Clin Immunol 1989; 9: 469–476 .

Blasini AM et al. T lymphocytes from patients with systemic lupus erythematosus show increased response to interleukin-2 after costimulation with OKT3 monoclonal antibody and phorbol esters . Clin Immunol Immunopathol 1994; 70: 66–72 .

Dayal A , Kammer G . The T cell enigma in lupus. Arthritis Rheum 1996; 39: 23–33. 10 Ohtsuka K et al. Decreased production of TGF-beta by lymphocytes from patients with systemic lupus erythematosus . J Immunol 1998; 160: 2539–2545 .

Stekman I et al. Enhanced CD3-mediated T lymphocyte proliferation in patients with systemic lupus erythematosus . Arthritis Rheum 1991; 34: 459–467 .

Vassilopoulos D , Kovacs B , Tsokos GC . TCR/CD3 complex-mediated signal transduction pathway in T cells and T cell lines from patients with systemic lupus erythematosus . J Immunol 1995; 155: 2269–2281 .

Weiss A , Littman D . Signal transduction by lymphocyte antigen receptors . Cell 1994; 76: 263–274 .

Cantrell D . T cell antigen receptor signal transduction pathways . Annu Rev Immunol 1996; 14: 259–274 .

Wange R , Samelson L . Complex complexes: signaling at the TCR . Immunity 1996; 5: 197–205 .

Matache C et al. Tyrosine phosphorylation in peripheral lymphocytes from patients with systemic lupus erythematosus . Autoimmunity 1996; 24: 217–228 .

Blasini A et al. Abnormal pattern of tyrosine phosphorylation in unstimulated peripheral blood T lymphocytes from patients with systemic lupus erythematosus. Lupus in press;

Liossis SN , Ding XZ , Dennis GJ , Tsokos GC . Altered pattern of TCR/ CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor zeta chain . J Clin Invest 1998; 101: 1448–1457 .

Takeuchi T et al. TCR zeta chain lacking exon 7 in two patients with systemic lupus erythematosus . Int Immunol 1998; 10: 911–921 .

Blasini A et al. Protein tyrosine kinase activity in T lymphocytes from patients with systemic lupus erythematosus. J Autoimmunity in press;

Trowbridge I , Thomas M . CD45: an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development . Annu Rev Immunol 1994; 12: 85–116 .

Samelson L , Phillips A , Luong E , Klausner R . Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor . Proc Natl Acad Sci U S A 1990; 87: 4358–4362 .

Takeuchi T et al. Reduced protein tyrosine phosphatase (PTPase) activity of CD45 on peripheral blood lymphocytes in patients with systemic lupus erythematosus (SLE) . Clin Exp Immunol 1997; 109: 20–26 .

Furukawa T et al. Specific interaction of the CD45 protein-tyrosine phosphatase with tyrosine-phosphorylated CD3 zeta chain . Proc Natl Acad Sci U S A 1994; 91: 10928–10932 .

Brundula V et al. Diminished levels of TCR zeta chains in peripheral blood T lymphocytes from patients with systemic lupus erythematosus. submitted;

Maurice M et al. Defective TCR-mediated signaling in synovial T cells in rheumatoid arthritis . J Immunol 1997; 159: 2973–2978 .

Sunder-Plassmann R et al. Functional analysis of immunoreceptor tyrosine-based activation motif (ITAM)-mediated signal transduction: the two YxxL segments within a single CD3zeta-ITAM are functionally distinct . Eur J Immunol 1997; 27: 2001–2009 .

Peyron J et al. The CD45 protein tyrosine phosphatase is required for the completion of the activation program leading to lymphokine production in the Jurkat human T cell line . Int Immunol 1991; 3: 1357–1366 .

Neumeister Kersh E , Shaw A , Allen P . Fidelity of T Cell Activation Through Multistep T Cell Receptor Phosphorylation . Science 1998; 281: 572–575 .

Lin S et al. The single positive T cells found in CD3-zeta/eta–/– mice overtly react with self-major histocompatibility complex molecules upon restoration of normal surface density of T cell receptor–CD3 complex . J Exp Med 1997; 185: 707–715 .

Yamazaki T et al. A shift from negative to positive selection of autoreactive T cells by the reduced level of TCR signal in TCRtransgenic CD3 zeta-deficient mice . J Immunol 1997; 158: 1634–1640 .

Shores EW et al. T cell development in mice lacking all T cell receptor zeta family members (Zeta, eta, and FcepsilonRIgamma) . J Exp Med 1998; 87: 1093–1101 .

Mohammadi M et al. Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors . Science 1997; 276: 955–960 .

Hibbs ML et al. Multiple defects in the immune system of Lyndeficient mice, culminating in autoimmune disease . Cell 1995; 83: 301–311 .

Nishizumi H et al. Impaired proliferation of peripheral B cells and indication of autoimmune disease in Lyn-deficicent mice . Immunity 1995; 3: 549–560 .

Huck S , Zouali M . Expression of the tyrosine kinase Lyn during B-cell receptor engagement and apoptosis . Ann N Y Acad Scie 1997; 815: 122–123 .

Liossis SN et al. B cells from patients with systemic lupus erythematosus display abnormal antigen receptor-mediated early signal transduction events . J Clin Invest 1996; 98: 2549–2557 .