Restricted accessOtherFirst published online 2003-11
The two hit hypothesis in the antiphospholipid syndrome: acute ischaemic heart involvement after valvular replacement despite anticoagulation in a patient with secondary APS
A patient with the antiphospholipid syndrome (APS), in whom a nonfatal myocardial infarction ensued after valvular heart replacement despite anticoagulation, is described. The report further stresses the role of concomitant risk co-factors in inducing thrombotic events and points out that cardiosurgery might represent a potential major risk for myocardial ischaemic damage in APS.
Wilson WA , Gharavi AE , Koike Tet al.International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop . Arthritis Rheum1999; 42: 1309-1311 .
2.
Cervera R , Piette JC , Font Jet al.Euro-Phospholipid Project Group . Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients . Arthritis Rheum2002; 46: 1019-1027 .
Cimaz R , Romeo A , Scarano Aet al.Prevalence of anti-cardiolipin, anti-beta2 glycoprotein I, and anti-prothrombin antibodies in young patients with epilepsy . Epilepsia2002; 43: 52-59 .
5.
Nochy D , Daugas E , Huong DLT , Piette JC , Hill G.Kidney involvement in the antiphospholipid syndrome . J Autoimmun2000; 15: 127-132 .
6.
Oldham HN , Roe CR , Young WG , Dixon SH.Intraoperative detection of myocardial damage during coronary artery surgery by plasma creatinine phosphokinase isoenzyme analysis . Surgery1973; 74: 917-925 .
7.
Cines DB , Pollak ES , Buck CAet al.Endothelial cells in physiology and in the pathophysiology of vascular disorders . Blood1998; 91: 3527-3561 .
8.
Bombeli T , Karsan A , Tast JF , Harlan JM.Apoptotic vascular endothelial cells become pro-coagulant . Blood1997; 89: 2429-2442 .
