Neutrophilic eccrine hidradenitis mimicking cutaneous vasculitis in a lupus patient: a complication of cyclophosphamide

Abstract

Neutrophilic eccrine hidradenitis (NEH) is an unusual self-limited skin disorder characterized by an inflammatory cell infiltrate in the deep dermis involving the eccrine sweat glands, commonly presenting as painful cutaneous nodules. NEH occurs most frequently in patients receiving chemotherapy for haematologic malignancies. We report a case of NEH masquerading as cutaneous vasculitis in a woman receiving cyclophosphamide for lupus nephritis. The association of NEH and the use of cytotoxic agents for SLE or other autoimmune diseases has not been reported previously. NEH must be considered in lupus patients receiving cytotoxic agents to avoid inappropriate use of corticosteroids or antibiotics in this self-limited condition.

Keywords

neutrophilic eccrine hidradenitis systemic lupus erythematosus

Get full access to this article

View all access options for this article.

References

Aractingi S. Neutrophilic dermatoses during granulocytopenia . Arch Dermatol 1995; 131: 1141-1145 .

Burg G , Bieber T , Langecker P. Localized neutrophilic eccrine hydradenitis in mitoxantrone therapy: a typical side-effect of cytostatic drugs . Hautarzt 1988; 39: 233-236 .

Kanzaki H , Oono T , Makino E , Arata J , Oda M , Akazai A. Neutrophilic eccrine hidradenitis: report of two cases . J Dermatol 1995; 22: 137-142 .

Keane FM , Munn SE , Buckley DA , Hopster D , Mufti GJ , du Vivier AW. Neutrophilic eccrine hidradenitis in two neutropaenic patients . Clin Exp Dermatol 2001; 26: 162-165 .

Nikkels AF , Hansen I , Collignon J , Fassotte MF , Fillet G , Pierard GE. Neutrophilic eccrine hidradenitis. A case report . Acta Clin Belg 1993; 48: 397-400 .

Pierson JC , Helm TN , Taylor JS , Elston DM , Tuthill RJ. Neutrophilic eccrine hidradenitis heralding the onset of acute myelogenous leukemia . Arch Dermatol 1993; 129: 791-792 .

Okcu A , Soyer HP , Kaddu S , Lackner H , Aberer E. Eccrine hidradenitis. Case report and review of the literature . Hautarzt 1997; 48: 743-748 .

Bilic M , Mutasim DF. Neutrophilic eccrine hidradenitis in a patient with Behçet’s disease . Cutis 2001 68: 107-111 .

Sevila A , Morell A , Banuls J , Silvestre JF , Betlloch I. Neutrophilic eccrine hidradenitis in an HIV-infected patient . Int J Dermatol 1996; 35: 651-652 .

10.

Tojo M , Iwatsuki K , Furukawa H , Takahashi M , Kaneko F. Neutrophilic eccrine hidradenitis in actinic reticuloid syndrome . Eur J Dermatol 2002; 12: 198-200 .

11.

Manganoni AM , Facchetti F , Gavazzoni R , Marocolo D , De Panfilis G. Neutrophilic eccrine hidradenitis in a healthy woman . Dermatology 1994; 189: 211-212 .

12.

Bachmeyer C , Aractingi S. Neutrophilic eccrine hidradenitis . Clin Dermatol 2000; 18: 319-330 .

13.

Ostlere LS , Wells J , Stevens HP , Prentice G , Rustin MH. Neutrophilic eccrine hidradenitis with an unusual presentation . Br J Dermatol 1993; 128: 696-698 .

14.

Ben-Amitae D , Hokak E , Landau M , Metzker A , Feinmegger M , David M. Idiopathic palmoplanar eccrine hidradenitis in children . Eur J Pediatr 2001; 160: 189-191 .

15.

Margolis DJ , Gross PR. Neutrophilic eccrine hidradenitis: a case report and review of the literature . Cutis 1991; 48: 198-200 .

16.

Shear NH , Knowles SR , Shapiro L , Poldre P. Dapsone in prevention of recurrent neutrophilic eccrine hidradenitis . J Am Acad Dermatol 1996; 35: 819-822 .