A personal account is given: 1) of my early work with lupus erythematosus including the first observation of formation of the LE cell and the experimental production in animal renal glomeruli of hematoxyphil bodies, the pathognomonic lesion of lupus; and, 2) of how discontinuationof work on lupus - by decree - diverted my life in science away from immunology into another area of human genetics, namely cytogenetics, the discovery of genetically determined genomic instability and the choice of Bloom’s syndrome as an investigational model for human cancer.
German JL.Studies in the pathogenesis of lupus erythematosus: experimental production of hematoxyphil bodies in the kidney . J Exp Med1958; 108: 179-184 .
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German JL , Huber M.Frozen cells as nuclear source in the L.E. cell phenomenon . Proc Soc Exp Biol Med1958; 97: 221-223 .
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German J.Cytological evidence for crossing-over in vitro in human lymphoid cells . Science1964; 144: 298-301 .
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Lejeune J , Gauthier J , Turpin R.Les chromosomes humains en culture de tissues . C R Acad Sci1959; 248: 602-603 .
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Hsu TC , Pomerat CM.Mammalian chromosomes in vitro. II. A method for spreading the chromosomes of cells in tissue culture . J Hered1953; 44: 23-29 .
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German J.The pattern of DNA synthesis in the chromosomes of human blood cells . J Cell Biol1964; 20: 37-55 .
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German J , Aronian D.Autoradiographicstudiesof human chromosomes. VI. Comparison of the end-of-S patterns in lymphocytes and amniotic epithelial cells . Chromosoma1971; 35: 99-110 .
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German JL.DNA synthesis in human chromosomes . Trans NY Acad Sci1962; 24: 395-407 .
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Bloom D.Congenital telangiectatic erythema resembling lupus erythematosus in dwarfs . Am J Dis Child1954; 88: 754-758 .
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German J , Archibald R , Bloom D.Chromosomal breakage in a rare and probably genetically determined syndrome of man . Science1965; 148: 506-507 .
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German JL , DeMayo AP , Bearn AG.Inheritance of an abnormal chromosome in Down’s syndrome (mongolism) with leukemia . Am J Hum Genet1962; 14: 31-43 .
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German J.Bloom syndrome: a mendelian prototype of somatic mutational disease . Medicine1993; 72: 393-406 .
