Street conversations with Henry Kunkel

Abstract

Nineteen eighty two was a fertile time for lupus research on York Avenue. The molecular and functional characteristics of the lupus autoantigens were being discovered by the newly introduced technologies, immunoprecipitation and western blotting. Were the antigens providing the essential clue to the cause of lupus? Was it their intracellular location? Was it their function? Was it their immunochemical structure? Were they cross-reactive with foreign antigens? Henry Kunkel discusses.