Primary antiphospholipid antibody syndrome masquerading as progressive supranuclear palsy

Abstract

We report a case of a patient with clinical features of progressive supranuclear palsy and raised titres of anticardiolipin antibodies in blood, thrombocytopenia and livedo reticularis on skin. Magnetic resonance imaging of brain and isotope scan of brain were distinctive of vascular disorder.

Keywords

antiphospholipid antibody syndrome progressive supranuclear palsy anticardiolipin antibody lupus anticoagulant

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References

Wilson WA , Gharavi AE , Koike T et al. International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop . Arthritis Rheum 1999; 42(7): 1309-1311 .

Victor M , Ropper AH. Progressive supranuclear palsy. In Adams , Victor M (eds). Principles of Neurology, 7th edn. McGraw-Hill: New York , 2001, pp 1138-1140.

Dubinski RM , Jankovic J. Progressive supranuclear palsy and multi-infarct state . Neurology 1987; 37(4): 570-576 .

Steele JC , Richardson J , Olszewski J. Progressive supranuclear palsy: a heterogenous degeneration involving the brainstem, basal ganglia and cerebellum with vertical gaze palsy and pseudobulbar palsy, nuchal dystonia, and dementia . Arch Neurol 1964; 2: 473-486 .

Brey RL , Hart RG , Sherman DG , Tegeler CH. Antiphospholipid antibodies and cerebral ischemia in young people . Neurology 1990; 40: 1190-1196 .

Tietjen GE , Day M , Norris L et al. Role of anticardiolipin antibodies in young persons with migraine and transient focal neurologic events: a prospective study . Neurology 1998; 50(5): 1433-1440 .

Cervera R , Asherson RA , Font J et al. Chorea in the antiphopholipid syndrome. Clinical, radiologic, and immunologic characteristics of 50 patients from our clinics and the recent literature . Medicine (Balt) 1997; 76(3): 203-212 .

Coull BM , Bourdette DN , Goodnight SH Jr , Briley DP , Hart R. Multiple cerebral infarctions and dementia associated with anticardiolipin antibodies . Stroke 1987; 18(6): 1107-1112 .

Levine SR , Brey RL. Neurological aspects of antiphospholipid antibody syndrome . Lupus 1996; 5: 347-353 .

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Mochizuki H , Okano M , Nagata N , Kamakura K.

[A case of Sjogren’s syndrome with a high titer of anticardiolipin antibody that developed as parkinsonism.]

Rinsho Shinkeigaku 1997; 37(1): 57-59 . (In Japanese.)