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Abstract

Our increased understandingof the pathogenesisof systemic lupus erythematosus is leading to new ideas about its therapy. In this session of the workshop the use of LJP 394 a B cell toleragen and the use of an anti-CD20 monoclonal antibody were discussed in some detail. Their rationale and early clinical results were reviewed; both have shown encouraging clinical and serological benefi t. Defi nitive double-blind clinical trials are still, however, awaited. In addition, the intriguing notion of using a nasal instillation of a histone peptide was described and early work in an experimental model presented.

Keywords

SLE anti DNA antibody histone peptide

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Workshop report on some new ideas about the treatment of systemic lupus erythematosus

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