Sex hormone adjuvanting therapy in rheumatoid arthritis

Ford DK. Understanding rheumatoid arthritis . J Rheumatol 1997; 24: 1464-1464 .

Cutolo M , Accardo S. Evers AWM , Kraaimaat FW , Geenen R et al. Psychosocial predictors of functional change in recently diagnosed rheumatoid arthritis patients . Behav Res Ther 1998; 36: 179-179 .

Cutolo M , Seriolo B , Pizzorni C , Sulli A . The role of androgens in rheumatic diseases . Israel Med Ass J 2001; 3: 743–748 .

Cutolo M , Sulli A , Seriolo B et al. Estrogens, the immune response and autoimmunity . Clin Exp Rheumatol 1995; 13: 217–217 .

Cutolo M , Straub R . Recent aspects of gonadal hormones and neurotrasmitter interactions with synovial cells in rheumatoid arthritis . Ann Rheum Dis 2000; 59: 657–661 .

Cutolo M , Wilder R . Different roles for androgens and estrogens in the susceptibility to autoimmune rheumatic diseases . Rheum Dis Clin N Am 2000; 26: 825–839 .

Masi AT , Feigenbaum SL , Chatteron RT et al. Integrated hormonalimmunological-vascular (H-I-V) systems interactions in the rheumatic diseases . Clin Exp Rheumatol 1995; 13: 203-203 .

Cutolo M , Seriolo B , Villaggio B , Pizzorni C , Craviotto C , Sulli A . Androgens and estrogens modulate the immune and inflammatory responses in rheumatoid arthritis . Ann NY Acad Sci 2002; 966: 131-131 .

Cutolo M . The roles of steroid hormones in arthritis . Br J Rheumatol 1998; 37: 597-597 .

Sohoni P , Sumpter JP . Several environmental estrogens are also anti-androgens . J Endocrinol 1998; 158: 327-327 .

Kelce WR , Stone CR , Laws SC et al. Persistent DDT metabolite p,p0-DDE is a potent androgen receptor antagonist . Nature 1995; 375: 581-581 .

Wang D , Chan EKL . b-Estradine increases expression of 52-kDa and 60 kDa SS-ARo autoantigens in human keratinocytes and breast cancer cell line MCF-7 . J Invest Dermatol 1996; 107: 610-610 .

Stone R . Environmental estrogens still debate . Science 1994; 265: 308-308 .

John S , Myerscough A , Eyre S et al. Linkage of a marker in intron D of the estrogen synthase locus to rheumatoid arthritis . Arthritis Rheum 1999; 42: 1617-1617 .

Masi AT , da Silva JAP , Cutolo M . Perturbations of the hypothalamic pituitary gonadal axis in rheumatoid arthritis. In: Chikanza IC (ed.), Neuroendocrine Immune Mechanisms of Rheumatic Diseases. Balliere's Clinical Rheumatology. London , 1996, p 245-245.

Wilder RL . Adrenal and gonadal steroid hormone de” ciency in the etiopathogenesis of rheumatoid arthritis . J Rheumatol 1996; 23(Suppl): 1–12 .

Walker JG , Littlejohn G , McMurray NE et al. Stress system activation in rheumatoid arthritis a multilevel approach . Rheumatology 1999; 38: 1050-1050 .

Cutolo M , Prete C , Walker J . Is stress a factor in the pathogenesis in autoimmune rheumatic diseases? Clin Exp Rheum 1999; 17: 515-515 .

Huyser B , Parker JC . Stress and rheumatoid arthritis: an integrative review . Arthritis Care Res 1998; 11: 135-135 .

Conway SC , Creed FH , Symmons DPM . Life events and the onset of rheumatoid arthritis . J Psychosom Res 1994; 38: 837-837 .

Evers AWM , Kraaimaat FW , Geenen R et al. Psychosocial predictors of functional change in recently diagnosed rheumatoid arthritis patients . Behav Res Ther 1998; 36: 179-179 .

Potter PT , Zautra AJ . Stressful life events effects on rheumatoid arthritis disease activity . J Consult Clin Psychol 1997; 65: 319-319 .

Zautra AJ , Okun M , Robinson S et al. Life stress and lymphocyte alterations among rheumatoid arthritis patients . Health Psychol 1989; 8: 1-1 .

Cutolo M , Sulli A , Barone A et al. Macrophages, synovial tissue and rheumatoid arthritis . Clin Exp Rheumatol 1993; 11: 331-331 .

Nouri AME , Panayi GS . Cytokines and the chronic inflammation of rheumatic diseases. The presence of interleukin-1 in synovial fluids . Clin Exp Immunol 1984; 55: 295-295 .

Saxne T , Palladino MA , Heinegard D et al. Detection of tumor necrosis factor-a in rheumatoid arthritis fluid and serum . Arthritis Rheum 1988; 31: 1041-1041 .

Guerne PA , Zuraw BL , Vaughan JH et al. Synovium as a source of interleukin-6 in vitro contribution to local and systemic manifestations of arthritis . J Clin Invest 1989; 83: 585-585 .

Xu WD , Firestein GS , Teatle YR et al. Cytokines in chronic inflammatory arthritis I Granulocyte–macrophage colonystimulating factor in rheumatoid synovial effusions . J Clin Invest 1989; 83: 876-876 .

Firestein GS , Townsend K , Broide D et al. Cytokines in chronic inflammatory arthritis I Failure to detect T cell lymphokines (IL-2 and IL-3) and presence of macrophage colony-stimulating factor (CSF-1) and a novel mast cell growth factor in rheumatoid synovitis . J Exp Med 1988; 168: 1573-1573 .

Fava R , Olsen N , Kaski-Olja J. Active and latent forms of transforming factor beta activity in synovial effusions . J Exp Med 1989; 169: 291-291 .

Wilder RL , Elenkow IJ . Hormonal regulation of tumor necrosis factor-a, interleukin-12 and interleukin-10 production by activated macrophages . Ann NY Acad Sci 1999; 876: 14-14 .

Symons JA , Wood NC , Di Giovine FS et al. Soluble IL-2 receptor in rheumatoid arthritis . J Immunol 1988; 141: 2612-2612 .

Cutolo M , Accardo S , Villaggio B et al. Evidence for androgen receptors in the synovial tissue of rheumatoid arthritis patients and healthy controls . Arthritis Rheum 1992; 35: 1007-1007 .

Cutolo M , Accardo S , Villaggio B et al. Presence of estrogen binding sites in macrophage-like synoviocytes and CD8 ‡ CD29 ‡ CD45RO ‡ T lymphocytes in normal and rheumatoid synovia . Arthritis Rheum 1993; 36: 1087-1087 .

Cutolo M , Accardo S , Villaggio B et al. Androgen and estrogen receptors are present in primary cultures of human synovial macrophages . J Clin Endocrinol Metab 1996; 81: 820-820 .

Cutolo M , Carruba G , Villaggio B , Coviello D , Dayer JM , Campisi I , Miele M , Stefano R , Castagnetta LAM . The phorbol diester 12-0-tetradecanoylphorbol 13-acetate (TPA) upregulates the expression of estrogen receptors in human THP-1 leukemia cells . J Cell Biochem 2001; 83: 390–400 .

Hayaashi Y , Hiyoshi T , Takemura T et al. Focal lymphocytic in” ltration in the adrenal cortex of the elderly immunohistological analysis of in” ltrating lymphocytes . Clin Exp Immunol 1989; 77: 101-101 .

Gonzalez-Hernandez JA , Bornstein F , Ehrhart-Bornstein M et al. Macrophages within the human adrenal gland Morphological data for a possible local immune-neuroendocrine interaction . Cell Tissue Res 1994; 278: 201-201 .

Marx C , Bornstein SR , Wolkersdorfer GW et al. Relevance of major histocompatibility complex class II expression as a hallmark for the cellular differentiation in the human adrenal cortex . J Clin Endocrinol Metab 1997; 82: 3136-3136 .

Marx C , Wolkersdorfer GM , Bornstein SR . A new view on immuneadrenal interaction Role for Fas and Fas ligand? Neuroimmunomodulation 1998; 5: 5-5 .

Ehrhart-Bornstein M , Hinson JP , Bornstein SR et al. Intraadrenal interactions in the regulation of adrenocortical steroidogenesis . Endocr Rev 1998; 19: 101-101 .

Masi AT , Chrousos GP , Bornstein SR . Enigmas of adrenal androgen and glucocorticoid dissociation in premenopausal onset in rheumatoid arthritis . J Rheumatol 1999; 26: 247-247 .

Da Silva JAP , Larbre JP , Seed M et al. Sex differences in inflammation induced cartilage damage in rodens . J Rheumatol 1994; 21: 330-330 .

Cutolo M. Sex hormone adjuvating therapy in rheumatoid arthritis .Rheum Dis Clin N Am 2000; 26: 881–895 .

Margolis HM , Caplan PS . The effect of some steroids (testosterone propionate, desoxycorticosterone acetate and ascorbic acid, and 21-acetoxy-5-pregnenolone, artisone acetate, Wyeth) in rheumatoid arthritis . Ann Inte Med 1951; 34: 61-61 .

Bird HA , Burkinshaw L , Pearson D et al. A controlled trial of nandrolone decanoate in the treatment of rheumatoid arthritis in postmenopausal women . Ann Rheum Dis 1987; 46: 237-237 .

Cutolo M , Balleari E , Giusti M et al. Androgen replacement therapy in male patients with rheumatoid arthritis . Arthritis Rheum 1991; 34: 1-1 .

Booij A , Biewenga-Booij CM , Huber-Brunning O et al. Androgens as adjuvant treatment in postmenopausal patients with rheumatoid arthritis . Ann Rheum Dis 1996; 55: 811-811 .

Hall GM , Larbre JP , Spector TD et al. A randomized trial of testosterone therapy in males with rheumatoid arthritis . Br J Med 1996; 35: 568-568 .

Van Voolenhoven RF , Morabito LM , Engleman EG et al. Treatment of systemic lupus erythematosus with dehydroepiandrosterone:50 patients treated up to 12 months . J Rheumatol 1998; 25: 285-285 .

Petri M , Lahita R , McGuire J et al. Results of the GL710 (DHEA) multicenter steroid-sparing SLE study . Arthritis Rheum 1997; 40: S327-S327 .

Suzuki T , Suzuki N , Daynes RA et al. Dehydroepiandrosterone enhances IL-2 production and cytotoxic effector function of human T cells . Clin Immunol Immunopathol 1991; 61: 202-202 .

Cutolo M. Effects of gonadal androgens on adrenal androgens . Clin Endocrinol 1996; 44: 489-489 .

James WH . Further evidence that low androgen values are a cause of rheumatoid arthritis the response of rheumatoid arthritis to seriously stressful life events . Ann Rheum Dis 1997; 56: 566-566 .

Bhasin S , Bremmer WJ . Emerging issues in androgen replacement therapy . J Clin Endocrinol Metab 1997; 82: 3-3 .

Cutolo M , Sulli A , Giusti M et al. Increase in serum 5-androstane-3, 17-diol glucuronide (3-diol G) as a possible marker of the androgenmediated immunosuppressive activity exerted by cyclosporin A preliminary results . Clin Exp Rheumatol 1994; 12: 350-350 .

Cutolo M , Giusti M , Villaggio B et al. Testosterone metabolism and cyclosporin A treatment in rheumatoid arthritis . Br J Rheumatol 1997; 4: 433-433 .

Giltay EJ , van den Borden NEEM , Gooren LJG et al. Androgenizing effects of low-dose cyclosporin in male patients with early RA . Br J Rheumatol 1998; 37: 470-470 .

Cutolo M , Sulli A , Craviotto C , Felli L , Pizzorni C , Seriolo B , Villaggio B. Antiproliferative-antiinflammatory effects of methotrexate (MTX) and sex hormones on cultured differentiating myeloid monocytic cells (THP-1). Ann NY Acad Sci 966-966 (in press).

Masi AT , Feigenbhaum SL , Chatteron RT . Hormonal and pregnancy relationship in RA convergens effects with immunologic and micro-vascular systems . Semin Arthritis Rheum 1995; 25: 1-1 .

Bijlsma JWJ , van der Brink HR . Estrogens and rheumatoid arthritis .Am J Reprod Immunol 1992; 28: 231-231 .

Van der Brink HR , van Everdingen AA , van Wijk MJG et al. Adjuvant estrogen therapy does not influences disease activity in postmenopausal female patients with RA . Ann Rheum Dis 1993; 52: 862-862 .

Hall GM , Daniels M , Huskisson EC et al. A randomized controlled trial of the effect of hormone replacement therapy on disease activity in postmenopausal RA . Ann Rheum Dis 1994; 53: 112-112 .

Brennam P , Bankhead C , Silman A et al. Oral contraceptives and RA: results from a primary care-based incident case-control study . Arthritis Rheum 1997; 26: 817-817 .

Guerrero-Sanchez J , Karison EW , Liang MH et al. Past use of oral contraceptives and the risk of developing systemic lupus erythematosus . Arthritis Rheum 1997; 40: 804-804 .

Sthoeger ZM , Bentwich Z , Zinger H et al. The bene” cial effect of the estrogen antagonist, tamoxifen, on experimental systemic lupus rythematosus . J Rheumatol 1994; 21: 2231-2231 .

Jungers P , Kutten F , Liote F et al. Hormonal modulation in systemic lupus erythematosus preliminary clinical and hormonal results with cyproterone acetate . Arthritis Rheum 1985; 28: 1243-1243 .

Jungers P , Dougados M , Pelissier C et al. Lupus nephropathy and pregnancy report of 104 cases in 36 patients . Arch Intern Med 1982; 142: 771-771 .

Bijlsma JWJ , Straub RH , Masi AT , Lahita RG , Cutolo M. Neuroendocrine immune mechanisms in rheumatic diseases . Trends Immunol 2002; 23: 61-61 .

Kanda N , Tsuchda T , Tamaki K. Estrogen enhancement of antidouble-stranded DNA antibody and immunoglobulin G production in peripheral blood mononuclear cells from patients with systemic lupus erythematosus . Arthritis Rheum 1999; 42: 328-328 .