We report the case of a 72-year-old female with sarcoidosis who developed a central retinal artery occlusion in her left eye in association with persistently high titers of IgG anti-cardiolipin antibodies. Only two previous cases of antiphospholipid antibody syndrome in association with sarcoidosis have been reported. Our patient's vision stabilized on anti-coagulant therapy along with concomitant treatment of sarcoidosis-related uveitis with methotrexate.
Ina Y , Takada K , Yamamoto M . Antiphospholipid antibodies. A prognostic factor in sarcoidosis?Chest1994; 105: 1179–1183 .
2.
Satti SD , Bartholomew J , Gordon SM et al. Antiphospholipidantibody syndrome in a patient with neurosarcoidosis . Vasc Med1999; 4: 37–39 .
3.
Arthur MF , Yee MB . Pohapin, treatment of complicated sarcoidosis with infliximab anti-tumor necrosis factor-a therapy . Ann Intern Med2001; 135: 27–31 .
4.
Wilson WA , Gharavi AE , Koike T et al. International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome . Arthrit Rheum1999; 42: 1309–1311 .
5.
Thomas PD , Hunninghake GW . Current concepts on the pathogenesis of sarcoidosis . Am Rev Respir Dis1987; 135: 747–760 .
6.
Prasse A , Georgees CC , Biller H et al. Th1 cytokine pattern in sarcoidosis is expressed by bronchoalveoalveolar CD4‡ and CD8‡ T cells . Clin Exp Immunol2000; 122: 241–248 .
7.
Giotaki HA . Biochemical and immunological parameters of sarcoid patients in West Greece . Sarcoidosis1989;6: 135–137 .
8.
Weinberg I , Vasiliev L , Gotsman I . Anti-dsDNA antibodies in sarcoidosis . Sem Arth Rheum2000; 29: 328–331 .
9.
Morris AJ , Morris CR , Hernandez CR et al. Anticardiolipin antibodies developing during infliximab therapy . ACR2001; S373-S373 .
10.
Jonsdottir T , Bratt J , Klareskog L et al. Development of ACLA in patients treated with infliximab . Arthrit Rheum2001; S373-S373 .
