Lessons in lupus: the mighty mouse

Bielschowsky M , Helyer BJ , Howie JB . Spontaneous haemolytic anaemia in mice of the NZB/Bl strain . Proc Univ Otago Med Sch (NZ) 1959; 37: 911-918 .

Andrews BS , Eisenberg RA , Theofilopoulos AN et al. Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains . J Exp Med 1978; 148: 1198–1215 .

Datta SK , Patel H , Berry D . Induction of a cationic shift in IgG anti-DNA autoantibodies. Role of helper T cells with classical and novel phenotypes in three murine models of lupus nephritis . J Exp Med 1987; 165: 1252–1268 .

Tucker RM , Vyse TJ , Rozzo S , Roark CL , Izui S , Kotzin BL . Genetic control of gp70 autoantigen production and its influence on immune complex levels and nephritis in murine lupus . J Immunol 2000; 165: 1665–1672 .

Rudofsky UH , Evans BD , Balaban SL , Mottironi VD , Gabrielsen AE . Differences in expression of lupus nephritis in New Zealand mixed H2z homozygous inbred strains of mice derived from New Zealand black and New Zealand white mice . Origins and initial characterization. Lab Invest 1993; 68: 419–426 .

Morel L , Croker BP , Blenman KR et al. Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains . Proc Natl Acad Sci USA 2000; 97: 6670–6675 .

Murphy ED , Roths JB . New inbred strains . Mouse News Lett 1978; 58: 51–65 .

Bhandoola A , Yui K , Sigel RM et al. Gld and lpr mice: single gene mutant models for failed self tolerance . Int Rev Immunol 1994; 11: 231–244 .

Izui S , Ibnou-Zekri N , Fossati-Jimack L , Iwamoto M . Lessons from BXSB and related mouse models . Int Rev Immunol 2000; 19: 447–472 .

Luzina IG , Knitzer RH , Atamas SP et al. Vasculitis in the Palmerston North mouse model of lupus: phenotype and cytokine production profile of infiltrating cells . Arthritis Rheum 1999; 42: 561–568 .

Tsao BP . Lupus susceptibility genes on human chromosome 1 . Int Rev Immunol 2000; 19: 319–334 .

Borchers A , Ansari AA , Hsu T , Kono DH , Gershwin ME . The pathogenesis of autoimmunity in New Zealand mice . Sem Arthrit Rheum 2000; 29: 385–399 .

Shevach EM . Regulatory T cells in autoimmunity . Annual Rev Immunol 2000; 18: 423–449 .

Singh RR , Hahn BH , Tsao BP , Ebling FM . Evidence for multiple mechanisms of polyclonal T cell activation in murine lupus . J Clin Invest 1998; 102: 1841–1849 .

Wofsy D , Seaman WE . Successful treatment of autoimmunity in NZB/NZW F1 mice with monoclonal antibody to L3T4 . J Exp Med 1985; 161: 378–391 .

Hahn BH . Animal Models of SLE. In: Wallace D , Hahn BH (eds). Dubois' Lupus Erythematosus, 6th edn. Lippincott, Williams and Wilkins: Baltimore MD , 2001 (in press).

Reininger L , Winkler TH , Kalberer CP , Jourdan M , Melchers F , Rolink AG . Intrinsic B cell defects in NZB and NZW mice contribute to systemic lupus erythematosus in (NZB×NZW)F1 mice . J Exp Med 1996; 184: 853–861 .

Tsao BP , Ohnishi K , Cheroutre H et al. Failed self-tolerance and autoimmunity in IgG anti-DNA transgenic mice . J Immunol 1992; 140: 350–358 .

Burlingame RW , Rubin RL . Autoantibody to the nucleosome subunit (H2A-H2B)-DNA is an early and ubiquitous feature of lupus-like conditions . Mol Biol Rep 1996; 23: 159–166 .

Kaliyaperumal A , Michaels MA , Datta SK . Antigen-specific therapy of murine lupus nephritis using nucleosomal peptides: tolerance spreading impairs pathogenic function of autoimmune T and B cells . J Immunol 1999; 162: 5775–5783 .

Hahn BH , Singh RR , Wong WK , Tsao BP , Bulpitt K , Ebling FM . Treatment with a consensus peptide based on amino acid sequences in autoantibodies prevents T cell activation by autoantigens and delays disease onset in murine lupus . Arthritis Rheum 2001; 444: 32–441 .

Mandik-Nayak L , Nayak S , Sokol C et al. The origin of anti-nuclear antibodies in bcl-2 transgenic mice . Int Immunol 2000; 12: 353–364 .

Taylor PR , Carugati A , Fadok V et al. A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo . J Exp Med 2000; 192: 359–366 .

Van Elven EG , Van Der Veen FM , Rolink AG et al. Diseases caused by reactions of T lymphocytes against incompatible structure of the major histocompatibility complex. V. High titers of IgG autoantibodies to double-stranded DNA . J Immunol 1983; 157: 755–771 .

Rus V , Svetic A , Nguyen P , Gause WC , Via CS . Kinetics of Th1 and Th2 cytokine production during the early course of acute and chronic murine graft-versus-host disease. Regulatory role of donor CD8/ T cells . J Immunol 1995; 55: 2396–2406 .

Sherer Y , Shoenfeld Y . The idiotypic network in antinuclear-antibodyassociated diseases . Int Arch Allergy Immunol 2000; 123: 10–15 .

Satoh M , Richards HB , Shaheen VM et al. Widespread susceptibility among inbred mouse strains to the induction of lupus autoantibodies by pristane . Clin Exp Immunol 2000; 121: 399–405 .

Scofield RH , Kaufman KM , Baber U , James JA , Harley JB , Kurien BT . Immunization of mice with human 60-kd Ro peptides results in epitope spreading if the peptides are highly homologous between human and mouse . Arthrit Rheum 1999; 42: 1017–1024 .

Mason LJ , Timothy LM , Isenberg DA , Kalsi JK . Immunization with a peptide of Sm B/B results in limited epitope spreading but not autoimmune disease . J Immunol 1999; 162: 5099–5105 .

Pisetsky DS . The antigenic properties of bacterial DNA in normal and aberrant immunity . Springer Sem Immunopathol 2000; 22: 153–166 .

Desai DD , Marion TN . Induction of anti-DNA antibody with DNA-peptide complexes . Int Immunol 2000; 12: 1569–1578 .

Kalled SL , Cutler AH , Datta SK , Thomas DW . Anti-CD40 ligand antibody treatment of SNF1 mice with established nephritis: preservation of kidney function . J Immunol 1998; 160: 2158–2165 .

Daikh DI , Wofsy D . Cutting edge: reversal of murine lupus nephritis with CTLA4Ig and cyclophosphamide . J Immunol 2001; 166: 2913–2916 .

Eilat E , Dayan M , Zinger H , Mozes E . The mechanism by which a peptide based on complementarity-determining region-1 of a pathogenic anti-DNA auto-Ab ameliorates experimental systemic lupus erythematosus . Proc Natl Acad Sci USA 2001; 98: 1148–1153 .

Gross JA , Johnston J , Mudri S et al. TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease . Nature 2000; 404: 995–999 .

Gaynor B , Putternman C , Valadon P , Spatz L , Scharff MD , Diamond B . Peptide inhibition of glomerular deposition of an anti-DNA antibody . Proc Natl Acad Sci USA 1997; 94: 1955–1960 .

Alarcon-Segovia D , Tumlin J , Furie R et al. SLE trial shows fewer renal flares in LJP 394-treated patients with high-affinity antibodies to LJP 394:90-05 trial results . Lupus 2001; 10: S94–S94 (abstract).

Kirzner RP , Engelman RW , Mizutani H , Specter S , Good RA . Prevention of coronary vascular disease by transplantation of T-celldepleted bone marrow and hematopoietic stem cell preparation in autoimmune-prone w/BF(1) mice . Biol Blood Marrow Transpl 2000; 6: 513–522 .

Ozmen L , Roman D , Fountoulakis M , Schmid G , Ryffel B , Garotta GF . Experimental therapy of systemic lupus erythematosus: the treatment of NZB/W mice with mouse soluble interferon-gamma receptor inhibits the onset of glomerulonephritis . Eur J Immunol 1995; 25: 6–12 .

Jacob CO and McDevitt HO. Tumour necrosis factor-alpha in murine autoimmune ‘lupus’ nephritis . Nature 1988; 331: 421–434 .

Gordon C , Ranges GE , Greenspan JS , Wofsy D . Chronic therapy with recombinant tumor necrosis factor-alpha in autoimmune NZB/NZWF1 mice . Clin Immunol Immunopathol 1989; 52: S141–S141 .

Jones BM , Liu T , Wong RW . Reduced in vitro production of interferon-gamma, interleukin-4 and interleukin-12 and increased production of interleukin-6, interleukin-10 and tumour necrosis factor-alpha in systemic lupus erythematosus. Weak correlations of cytokine production with disease activity . Autoimmunity 1999; 31: 117–124 .

Ishida H , Muchamuel T , Sakaguchi S , Andrade S , Menon S , Howard M . Continuous administration of anti-interleukin 10 antibodies delays onset of autoimmunity in NZB/W F1 mice . J Exp Med 1994; 179: 305–310 .

Raz E , Dudler J , Lotz M et al. Modulation of disease activity in murine systemic lupus erythematosus by cytokine gene delivery . Lupus 1995; 4: 286–292 .

Prud'homme GJ . Gene therapy of autoimmune diseases with vectors encoding regulatory cytokines or inflammatory cytokine inhibitors . J Gene Med 2000; 2: 222–232 .