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Abstract

The effect of dietary modifications has been extensively studied in lupus animal models. Calorie, protein, and especially fat restriction, caused a significant reduction in immune-complex deposition in the kidney, reduced proteinuria and prolongation of the mice's life span.

The addition of polyunsaturated fatty acids (PUFAs), such as fish oil or linseed oil, was also related to decreased mice morbidity and mortality in animal models of lupus and of antiphospholipid syndrome. PUFAs such as eicosapetaenoic acid (EPA) and docosahexaenoic acid (DHA) competitively inhibit arachidonic acid with a resultant decrease in inflammmatory eicosanoids and cytokines.

Human studies support the effect of a PUFAs-enriched diet, both scrologically and clinically. Large scale clinical studies are needed to confirm the primary results.

Keywords

lupus erythematosus polyunsaturated fatty acids (PUFAs)fish oil linseed oil autoimmune diseases

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References

Fernandes G , Friend P , Yunis EJ , Good RA. Influence of diet on survival of mice . Proc Natl Acad Sci USA 1978; 75: 1500–1506 .

Fernandes G , Yunis EJ , Good RA. Influence of protein restriction on immune functions in NZB mice . J Immunol 1976; 116: 782–785 .

Troyer DA , Chandrasekar B , Barnes JL , Fernandes G. Calorie restriction decreases platelet-derived growth factor (PDGF)-A and thrombin receptor mRNA expression in autoimmune murine lupus nephritis . Clin Exp Immunol 1997; 108: 58–62 .

Fernandes G , Yunis J , Smith J , Good RA. Dietary influence on breeding behaviour, hemolytic anemia and longevity in NZB mice . Proc Soc Exp Biol Med 1972; 139: 1189–1196 .

Lin BF , Jeng SJ , Chiano BL , Huang CC. Dietary fat affects lipids and anti-cardiolipin antibody levels in autoimmune-prone NZB/WF1 mice . Br J Nutr 1997; 77: 657–669 .

Lin BF , Huang CC , Chiang BL , Jeng SJ. Dietary fat influences la antigen expression, cytokines and prostaglandin E2 production of immune cells in autoimmune-prone NZB*NZW F1 mice . Br J Nutr 1996; 75: 711–722 .

Betz M , Fox BS. Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lumphokines . J Immunol 1991; 146: 108–113 .

Calder PC. N-3 polyunsaturated fatty acids and cytokine production in health and disease . Ann Nutr Metab 1997; 41: 203–234 .

Yaqoob P , Calder PC. Effects of dietary lipid manipulation upon inflammatory mediator production by murine macrophages . Cell Immunol 1995; 163: 120–128 .

10.

Black JM , Kinsella JE. Dietary n-3 fatty-acids alter mouse peritoneal macrophage cytotoxicity . Ann Nutr Metabol 1993; 37: 110–120 .

11.

Pricket JD , Robinson DR , Steinberg AD. Effects of dietary enrichment with eicosapentaenoic acid upon autoimmune nephritis in female NZB*NZW/Fl mice . Arthritis Rheumatol 1983; 26: 133–139 .

12.

Lim BO , Jolly CA , Zaman K , Fernandes G. Dietary (n-6) and (n-3) fatty acids and energy restriction modulate mesenteric lymph node lymphocyte function in autoimmune-prone (NZB*NZW) Fl mice . J Nutr 2000; 130: 1657–1664 .

13.

Reifen R , Blank M , Afek A et al. Dietary polyunsaturated fatty acids decrease anti-dsDNA and anti-cardiolipin antibodies production in idiotype induced mouse model of systemic lupus erythematosus . Lupus 1998; 7: 192–197 .

14.

Reifen R , Amital H , Blank M et al. Linseed oil supressed the anti-beta-2-glycoprotein-I in experimental antiphospholipid syndrome . J Autoimmune (in press).

15.

Beach RS , Gershwin ME , Hurley LS. Nutritional factors and autoimmunity II . Prolongation of survival in zinc-deprived NZB/W mice. J Immunol 1982; 128: 308–313 .

16.

O'Dell JR , McGivern JP , Kay HD Klassen LW. Improved survival in murine lupus as the result of selenium supplementation . Clin Exp Immunol 1988; 73: 322–327 .

17.

Leiter LM , Reuhl KR , Racis SP , Sherman AR. Iron status alters murine systemic lupus crythematosus . J Nutr 1995; 125: 474–484 .

18.

Endres S , Ghorbani R , Kelley VE et al. The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor neerosis factor by mononuclear cells . New Engl J Med 1989; 320: 265–271 .

19.

Robinson DR , Xu LL , Tateno S , Guo M , Colvin RB. Supression of autoimmune disease by dietary n-3 fatty acids . J Lipid Res 1993; 34: 1435–1444 .

20.

Rossi E , Costa M. Fish oil derivatives as a prophylaxis of recurrent miscarriage associated with antiphospholipid antibodies (APL): a pilot study . Lupus 1993; 2: 319–323 .

Diet and lupus

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