Benzydamine is a nonsteroidal anti-inflammatory drug, currently available as mouthwash, aerosol, dermal cream, vaginal douche preparation, pills and otic drops. Up to now no cases of poisoning due to this drug have been reported. A 6-year-old girl with an accidental poisoning with benzydamine is described. The episode consisted of hallucinosis without other symptoms and resolved spontaneously in 17 h.
Fanaki NH , el-Nakeeb MA . Antimicrobial activity of benzydamine, a non-steroid anti-inflamatory agent . JChemother1992; 4: 347-352 .
2.
BaldockGA et al. Pharmacokinetics of benzydamine after intravenous, oral, and topical doses to human subjects . Biopharm Drug Dispos1991; 12: 481-492 .
3.
Anfossi P et al. Pharmacokinetics of benzydamine in dairy cows following intravenous or intramuscular administration . Vet Res Commun1993; 17: 313-323 .
4.
Bright TP , McNulty CJ . Suspected central nervous system toxicity from inadvertent nonsteroidal antiinflammatory drug overdose . DICP1991; 25: 1066-1067 .
Smolinske SC et al. Toxic effects of nonsteroidal anti-inflammatory drugs in overdose. An overview of recent evidence on clinical effects and dose response relationships . Drug Saf1990; 5: 252-274 .
7.
Lo GC , Chan JY . Piroxicam poisoning . Br Med J1983; 287798-798 .
8.
Kolodzik JM , Eilers MA , Angelos MG . Nonesteroidal anti-inflamatory drugs and coma: a case report af fenoprofen overdose . Ann Emerg Med1990;19: 378-381 .
9.
Macdougall LG , Taylor-Smith A , Rothberg AD , Thomson PD . Piroxicam poisoning in a 2-year-old child. A case report . SAfrMedJ1984; 66: 31-33 .
10.
Mosvold J et al. Overdosage of piroxicam . Acta Med Scand1984; 216: 335-336 .
11.
Davies NM , Jamali F . Pharmacological protection of NSAID-induced intestinal permeability in the rat: effect of tempo and metronidazole as potential free radical scavengers . Hum Exp Toxicol1997; 16: 345-349 .
12.
Kulling EJ , Beckman EA , Skagius AS . Renal impairment after acute diclofenac, naproxen, and sulindac overdoses . J Toxicol Clin Toxicol1995; 35: 711-719 .
O'Callaghan CA , Andrews PA , Ogg CS . Renal disease and use of topical non-steroidal anti-inflammatory drugs . Brit Med J1994; 308: 110-111 .
15.
Gross GE . Granulocytosis and a sulindac overdose . AnnInternMed1982; 96: 793-794 .
16.
American Academy of Clinical Toxicology ; European Association of Poison Centres and Clinical Toxicologists . Position statement: gastric lavage . Clinical Toxicology1997; 35: 711-719 .