Redox signaling mechanisms and radiationinduced bystander effects

Redon C , Pilch D , Rogakou E , Sedelnikova O , Newrock K , Bonner W . Histone H2A variants H2AX and H2AZ . Curr Opin Genet Dev 2002; 12: 162-169 .

Ward IM , Minn K , Jorda KG , Chen J . Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX . J Biol Chem 2003; 278: 19579-19582 .

Rothkamm K , Lobrich M . Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses . Proc Natl Acad Sci 2003; 100: 5057-5062 .

Wu LJ , Randers-Pehrson G , Xu A , Waldren CA , Geard CR , Yu Z , Hei TK . Targeted cytoplasmic irradiation with alpha particles induces mutations in mammalian cells . Proc Natl Acad Sci 1999; 96: 4959-4964 .

Haimovitz-Freidman A , Kan C-C , Ehleiter D , Persaud R , McLaughlin M , Fuks, Z , Kolesnick R . Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis . J Exp Med 1994; 180: 525-535 .

Hallahan DE , Sukhatme VP , Sherman ML , Virudachalam S , Kufe D , Weichselbaum RR . Protein kinase C mediates x-ray inducibility of nuclear signal transducers EGR1 and JUN . Proc Natl Acad Sci 1991; 88: 2156-2160 .

Todd D , Mikkelsen RB . Ionizing radiation induces a transient increase in cytosolic free [Ca2+] in human epithelial tumor cells . Cancer Res 1994; 54: 5224-5230 .

Schmidt-Ullrich R , Dent P , Grant S , Mikkelsen RB , Valerie K . Signal transduction and cellular radiation responses . Radiat Res 2000; 153: 245-257 .

Tuttle S , Horan AM , Koch CJ , Held K , Manevich Y , Biaglow J . Radiation-sensitive tyrosine phosphorylation of cellular proteins: sensitive to changes in GSH content induced by pretreatment with N-acetyl-L-cysteine or L-buthionine-S,R-sulfoximine . Int J Rad Oncol Biol Phys 1998; 42: 833-838 .

Kavanagh B , Todd D , Chen P , Schmidt-Ullrich RK , Mikkelsen RB . Calcium-dependent stimulation of mitogen-activated protein kinase activity in A431 cells by low doses of ionizing radiation . Radiat Res 1998; 149: 579-587 .

Stephenson MA , Pollock S , Coleman NC , Calderwood S . X-irradiation , phorbol esters , and H2O2 stimulate mitogen-activated protein kinase activity in NIH-3T3 cells through the formation of reactive oxygen intermediates . Cancer Res 1994; 54: 12-15 .

Ward J . DNA damage as the cause of ionizing radiation-induced gene activation . Radiat Res 1994; 138: S85-S88 .

Leach JK , Van Tuyle G , Lin P-S , Schmidt-Ullrich RK , Mikkelsen RB . Ionizing radiation-induced, mitochondria-dependent generation of reactive oxygen/nitrogen . Cancer Res 2001; 61: 3894-3901 .

Leach JK , Black SM , Schmidt-Ullrich RK , Mikkelsen RB . Activation of constitutive nitric-oxide synthase activity is an early signaling event induced by ionizing radiation . J Biol Chem 2002; 277: 15400-15406 .

Clutton S , Townsend K , Walker C , Ansell J , Wright E . Radiation-induced genomic instability and persisting oxidative stress in primary bone marrow cultures; 1996.

Morales A , Miranda M , Sanchez-Reyes A , Biete A , Fernandez-Checa J . Oxidative damage of mitochondrial and nuclear DNA induced by ionizing radiation in human hepatoblastoma cells . Int J Rad Oncol 1998; 42: 191-204 .

Narayanan PK , Goodwin EH , Lehnert BE . Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells . Cancer Res 1997; 57: 3963-3971 .

Paris R , Morales A , Coll O , Sanchez-Reyes A , Garcia-Ruiz C , Fernandez-Checa JC . Ganglioside GD3 sensitizes human hepatoma cells to cancer therapy . J Biol Chem 2002; 277: 49870-49876 .

Zorov DB , Filburn CR , Klotz L-O , Zweier JL , Sollott SJ . Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes . J Exp Med 2000; 192: 1001-1014 .

Droge W . Free radicals in the physiological control of cell function . Physiol Rev 2001; 82: 47-95 .

Paxinou E , Weisse M , Chen Q , Souza JM , Hertkorn C , Selak M , Daikhin E , Yudkoff M , Sowa G , Sessa WC , Ischiropoulos H . Dynamic regulation of metabolism and respiration by endogenously produced nitric oxide protects against oxidative stress . Proc Natl Acad Sci 2001; 98: 11575-11580 .

Ichas F , Mazat JP . From calcium signaling to cell death: two conformations for the mitochondrial permeability transition pore. Switching from low-to high-conductance state . Biochim Biophys Acta 1998; 1366: 33-50 .

Mikkelsen, RB and Wardman P . Biological chemistry of reactive oxygen and nitrogen and radiation-induced signal transduction mechanisms . Oncogene Rev 2003; 22: 5734-5754 .

Gudz TI , Pandelova IG , Novgordov SA . Stimulation of respiration in rat thymocytes induced by ionizing radiation . Radiat Res 1994; 138: 219-228 .

Crompton M . The mitochondrial permeability transition pore and its role in cell death . Biochem J 1999; 341: 233-249 .

Bernardi P , Petronelli V . The permeability transition pore as a mitochondrial calcium release channel: a critical appraisal . J Bioenerg Biomembr 1996; 28: 131-138 .

Vercesi AE , Kowaltowski AJ , Grijalba MT , Meinicke AR , Castilho RF . The role of reactive oxygen species in mitochondrial permeability transition . Biosci Rep 1997; 17: 43-52 .

Giulivi C . Characterization and function of mitochondrial nitric-oxide synthase . Free Radic Biol Med 2003; 34: 397-408 .

Hess DT , Matsumoto A , Nudelman R , Stamler JS . S-nitrosylation: spectrum and specificity . Nature Cell Biol 2001; 3: E46-E49 .

Azzam EI , De Toledo SM , Spitz DR , Little JB . Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alphaparticle-irradiated normal human fibroblast cultures . Cancer Res 2002; 62: 5436-5442 .

Lehnert BE , Goodwin EH , Deshpande A . Extracellular factor(s) following exposure to alpha particles can cause sister chromatid exchanges in normal human cells . Cancer Res 1997; 57: 2164-2171 .

Halliwell B , Gutteridge JMC . Free radicals in biology and medicine, third edition. Oxford: Oxford University Press , 1997.

Shao C , Furusawa Y , Aoki M , Matsumoto H , Ando K . Nitric oxide-mediated bystander effect induced by heavy-ions in human salivary gland tumour cells . Int J Radiat Biol 2002; 78: 837-844 .

Ford E , Hughes MN , Wardman P . The reaction of superoxide radicals with S-nitrosoglutathione and the products of its reductive heterolysis . J Biol Chem 2002; 277: 2430-2436 .

Murphy BJ , Laderoute KR , Short SM , Sutherland RM . The identification of heme oxygenase as a major hypoxic stress protein in Chinese hamster ovary cells . Br J Cancer 1991; 64: 69-73 .

Zhang X , Shan P , Alam J , Davis RJ , Flavell RA , Lee PJ . Carbon monoxide modulates Fas/Fas ligand, caspases, and Bcl-2 family proteins via the p38alpha mitogenactivated protein kinase pathway during ischemiareperfusion lung injury . J Biol Chem 2003; 278: 22061-22070 .

Otterbein LE , Mantell LL , Choi AM . Carbon monoxide provides protection against hyperoxic lung injury . Am J Physiol 1999; 276: L688-L694 .

Zhou H , Suzuki M , Randers-Pehrson G , Vannais D , Chen G , Trosko JE , Waldren CA , Hei TK . Radiation risk to low fluences of alpha particles may be greater than we thought . Proc Natl Acad Sci 2001; 98: 14410-14415 .

Azzam EI , de Toledo SM , Little JB . Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha-particle irradiated to nonirradiated cells . Proc Natl Acad Sci 2001; 98: 473-478 .

Garcia-Fernandez AJ , Bayoumi AE , Perez-Pertejo Y , Romero D , Ordonez C , Reguera RM , Balana-Fouce R , Ordonez D . Changes in glutathione-redox balance induced by hexachlorocyclohexane and lindane in CHO-K1 cells . Xenobiotica 2002; 32: 1007-1016 .

Lu CH , Lee KC , Chen YC , Cheng JS , Yu MS , Chen WC , Jan CR . Lindane (gamma-hexachlorocyclohexane) induces internal Ca2+ release and capacitative Ca2+ entry in Madin-Darby canine kidney cells . Pharmacol Toxicol 2000; 87: 149-155 .

Kim YJ , Elliott AC , Moon SJ , Lee SI , Seo JT . Octanol blocks fluid secretion by inhibition of capacitative calcium entry in rat mandibular salivary acinar cells . Cell Calcium 1999; 25: 77-84 .

Stout CE , Costantin JL , Naus CC , Charles AC . Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels . J Biol Chem 2002; 277: 10482-10488 .

Plotkin LI , Bellido T . Bisphosphonate-induced, hemi-channel-mediated, anti-apoptosis through the Src/ERK pathway: a gap junction-independent action of connexin43 . Cell Commun Adhes 2001; 8: 377-382 .

Seymour CB , Mothersill C . Delayed expression of lethal mutations and genomic instability in the progeny of human epithelial cells that survived in a bystander-killing environment . Radiat Oncol Investig 1997; 5: 106-110 .

Nagar S , Smith LE , Morgan WF . Characterization of a novel epigenetic effect of ionizing radiation: the death-inducing effect . Cancer Res 2003; 63: 324-328 .

Lyng FM , Seymour CB , Mothersill C . Production of a signal by irradiated cells which leads to a response in unirradiated cells characteristic of initiation of apoptosis . Br J Cancer 2000; 83: 1223-1230 .

Lewis DA , Mayhugh BM , Qin Y , Trott K , Mendonca MS . Production of delayed death and neoplastic transformation in CGL1 cells by radiation-induced bystander effect . Radiat Res 2001; 156: 251-258 .

Dent P , Reardon DB , Park JS , Bowers G , Logsdon C , Valerie K , Schmidt-Ullrich R . Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death . Mol Biol Cell 1999; 10: 2493-2506 .

Narayanan PK , LaRue KE , Goodwin EH , Lehnert BE . Alpha particles induce the production of interleukin-8 by human cells . Radiat Res 1999; 152: 57-63 .

Xiong Q , Shi Q , Le X , Wang B , Xie K . Regulation of interleukin-8 expression by nitric oxide in human pancreatic adenocarcinoma . J Interferon Cytokine Res 2001; 21: 529-537 .

Lorimore SA , Wright EG . Radiation-induced genomic instability and bystander effects: related inflammatory type responses to radiation-induced stress and injury? A review . Int J Radiat Biol 2003; 79: 15-25 .