1 Guarente L , Kenyon C . Genetic pathways that regulate ageing in model organisms . Nature2000; 408: 255-262 .
2.
2 Migliaccio E , Giorgio M , Mele S , Pelicci G , Reboldi P , Pandolfi PP et al. The p66shc adaptor protein controls oxidative stress response and life span in mammals . Nature1999; 402(6759): 309-313 .
3.
3 Hass MA , Massaro D . Regulation of the synthesis of superoxide dismutase in rat lungs during oxidant and hyperthermic stresses . J Biol Chem1988; 263: 776-781 .
4.
4 Johnson TE , Lithgow GJ , Murakami S . Hypothesis: Interventions that increase the response to stress offer the potential for effective life prolongation and increased health . J Gerontol Biol Sci1996; 51A: B392-B395 .
5.
5 Morimoto RI , Tissieres A , Georgopoulos C . The Biology of Heat Shock Proteins and Molecular Chaperones. Cold Spring Harbor Laboratory Press, New York , 1994.
6.
6 Maynard Smith J . Prolongation of the life of Drosophila subobscura by brief exposure of adults to a high temperature . Nature1958; 181: 496-497 .
7.
7 Maynard Smith J . The effects of temperature and of egg- laying on the longevity of Drosophila subobscura . J Exp Biol1958; 35: 832-843 .
8.
8 Khazaeli AA , Tatar M , Pletcher SD , Curtsinger JW . Heat-induced longevity extension in Drosophila: I. Heat treatment, mortality, and thermotolerance . J Gerontol A Biol Sci Med Sci1997; 52: B48-B52 .
9.
9 Lithgow GJ , White TM , Melov S , Johnson TE . Thermo- tolerance and extended life span conferred by single- gene mutations and induced by thermal stress . Proc Natl Acad Sci USA1995; 92: 7540-7544 .
10.
10 Lithgow GJ , White TM , Hinerfeld DA , Johnson TE . Thermotolerance of a long-lived mutant of Caenorhab- ditis elegans . J Gerontol A Biol Sci1994; 49: B270-B276 .
11.
11 Parsell DA , Lindquist S . Heat shock proteins and stress tolerance. In: Morimoto RI , Tissieres A , Georgopoulos C (Eds), The Biology of Heat Shock Proteins and Molecular Chaperones. Cold Spring Harbor Laboratory Press, New York , 1994; pp. 457-494.
12.
12 Welte MA , Tetrault JM , Dellavalle RP , Lindquist SL . A new method for manipulating transgenes: engineering heat tolerance in a complex, multicellular organism . Curr Biol1993; 3: 842-853 .
13.
13 Tatar M , Khazaeli AA , Curtsinger JW . Chaperoning extended life . Nature1997; 390: 30-30 .
14.
14 Martin GM , Austad SN , Johnson TE . Genetic analysis of ageing: role of oxidative damage and environmental stresses . Nat Genet1996; 13: 25-34 .
15.
15 Honda Y , Honda S . The daf -2 gene network for longevity regulates oxidative stress resistance and Mn- superoxide dismutase gene expression in Caenorhabdi- hs elegans . FASEBJ1999; 13: 1385-1393 .