Applying hormesis in aging research and therapy: a commentary

1 Lithgow GJ , White TM , Melov S , Johnson TE . Thermo- tolerance and extended life-span conferred by single- gene mutations and induced by thermal stress . Proc Natl Acad Sci USA 1995; 92: 7540-7544 .

2 Lee CK , Klopp RG , Weindruch R , Prolla TA . Gene expression profile of aging and its retardation by caloric restriction . Science 1999; 285: 1390-1393 .

3 Zou S , Meadows S , Sharp L , Jan LY , Jan YN . Genome- wide study of aging and oxidative stress response in Drosophila melanogaster . Proc Natl Acad Sci USA 2000; 97: 13726-13731 .

4 Masoro EJ . Caloric restriction and aging: an update . Exp Gerontol 2000; 35: 299-305 .

5 Sacher GA . Life table modification and life prolongation. In: Finch CE , Hayflick L (Eds), Handbook of the Biology of Aging. Van Nostrand-Reinhold, New York , 1977; pp. 582-638.

6 IMinois N . Longevity and aging: beneficial effects of exposure to mild stress . Biogerontology 2000; 1: 15-29 .

7 Currie RW , Karmazyn M , Kloc M , Mailer K . Heat-shock response is associated with enhanced post-ischemic ventricular recovery . Circ Res 1988; 63: 543-549 .

8 Currie RW , Tanguay RM , Kingma JG . Heat-shock response and limitation of tissue necrosis during occlusion in rabbit hearts . Circulation 1993; 87: 963-971 .

9 Leppa S , Sistonen L . Heat shock response - pathophy- siological implications . Ann Med 1997; 29: 73-78 .

10 Benjamin IJ , McMillan DR . Stress (heat shock) proteins molecular chaperones in cardiovascular biology and disease . Circ Res 1998; 83: 117-132 .

11 Chong KY , Lai CC , Lille S , Chang C , Su CY . Stable overexpression of the constitutive form of heat shock protein 70 confers oxidative protection . J Mol Cell Cardiol 1998; 30: 599-608 .

12 Hoffmann AA , Parsons PA . Evolutionary Genetics and Environmental Stress. Oxford Univ. Press, Oxford , 1991.

13 Su CY , Chong KY , Owen OE , Dillmann WH , Chang C , Lai CC . Constitutive and inducible hsp7os are involved in oxidative resistance evoked by heat shock or ethanol . J Mol Cell Cardiol 1998; 30: 587-598 .

14 Shama S , Lai CY , Antoniazzi JM , Jiang JC , Jazwinski SM . Heat stress -induced life span extension in yeast . Exp Cell Res 1998; 245: 379-388 .

15 Minois N , Khazaeli AA , Curtsinger JW . Locomotor activity as a function of age and life span in Drosophila melanogaster overexpressing hsp7o. Exp Gerontol . In Press.