1 Baasner S , von Melchner H , Klenner T , Hilgard P , Beckers T . Reversible tumorigenesis in mice by conditional expression of the HER2/c-erbB2 receptor tyrosine kinase . Oncogene. 1996; 13: 901-911 .
2.
2 Baylin SB . Tying it all together: epigenetics, genetics, cell cycle, and cancer . Science. 1997; 277: 1948-1949 .
3.
3 Clark GJ , Kinch MS , Gilmer TM , Burridge K , Der CJ . Overexpression of the ras-related TC21/R-ras2 protein may contribute to the development of human breast cancers . Oncogene. 1996; 12: 169-176 .
4.
4 Counts JL , Goodman JI . Alterations in DNA methylation may play a variety of roles in carcinogenesis . Cell. 1995a; 83: 13-15 .
5.
5 Counts JL , Goodman JI . Hypomethylation of DNA: a possible epigenetic mechanism involved in tumor promotion. In: McLain RM , Slaga TJ , LeBoeuf RA , Pitot HC (Eds.), Growth Factors and Tumor Promotion: Implications for Risk Assessment. Wiley-Liss, NY , 1995b, pp. 81-101.
6.
6 Counts JL , Goodman JI . Hypomethylation of DNA: an epigenetic mechanism that can facilitate the aberrant oncogene expression involved in liver carcinogenesis. In: Jirtle R (Ed.), Liver Regeneration and Carcinogenesis. Academic Press, NY , 1995c, pp. 227-255.
7.
7 Dragan YP , Sargent L , Xu YD , Xu YH , Pitot HC . The initiation, promotion, progression model of rat hepatocarcinogenesis . Proc Soc Exp Biol Med. 1993; 202: 16-24 .
8.
8 Hepburn PA , Margison GP , Tisdale MJ . Enzymatic methylation of cytosine in DNA is prevented by adjacent O6-methylguanine residues . J Biol Chem. 1991; 266: 7985-7987 .
9.
9 Holiday R . DNA methylation and epigenetic defects in carcinogenesis . Mutat Res. 1987; 181: 215-217 .
10.
10 Holiday R . Epigenetics: an overview . Dev Genet. 1994; 15: 453-457 .
11.
11 Jones PA , Laird PW . Cancer epigenetics comes of age . Nat Genet. 1999; 21: 163-167 .
12.
12 Lee LW , Raymond VW , Tsao M-S , Lee DC , Earp HS , Grisham JW . Clonal cosegregation of tumorigenicity with over expression of c-myc and transforming growth factor a genes in chemically transformed rat liver epithelial cells . Cancer Res. 1991; 51: 5238-5244 .
13.
13 Mangues R , Kahn JM , Seidman I , Pellicer A . An overexpressed N-ras proto-oncogene cooperates with N-methylnitrosourea in mouse mammary carcinogenesis . Cancer Res. 1994; 54: 6395-6401 .
14.
14 Ray JS , Harbison ML , McClain RM , Goodman JI . Alterations in the methylation status and expression of the raf oncogene in phenobarbital-induced and spontaneous B6C3F1 mouse liver tumors . Mol Carcinogen. 1994; 9: 155-166 .
15.
15 Samiec PS , Goodman JI . Evaluation of methylated DNA binding protein-1 in mouse liver . Toxicol Sci. 1999; 49: 255-262 .
16.
16 Schwab M , Alitalo K , Varmus HE , Bishop JM . Nature. 1983; 303: 497-501 .
17.
17 Shastry BS . Overexpression of genes in health and sickness . Comp Biochem Physiol. 1995; 112B: 1-13 .
18.
18 Singh P , Wong SH , Hong W . Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation . EMBO J. 1994; 13: 3329-3338 .
19.
19 Tan N-W , Li BF . Interaction of oligonucleotides containing 6-O-methylguanine with human DNA (cytosine-5-)-methyltransferase . Biochemistry. 1990; 29: 9234-9240 .
20.
20 Trosko JE , Chang CC , Upham B , Wilson M . Epigenetic toxicology as toxicant-induced changes in intracellular signaling leading to altered gap junctional intercellular communication . Toxicol Lett. 1998; 102-103: 71-78 .
21.
21 US Environmental Protection Agency . Proposed guide-lines for carcinogen risk assessment . Fed Reg. 1996; 61: 17960-18011 .
22.
22 Weitzman SA , Turk PW , Milkowski DH , Kozlowski K . Free radical adducts induce alterations in DNA cytosine methylation . Proc Natl Acad Sci USA. 1994; 91: 1261-1264 .
23.
23 Wilson VL , Jones PA . Inhibition of DNA methylation by chemical carcinogens in vitro . Cell. 1983; 32: 239-246 .
24.
24 Wilson VL , Smith RA , Longoria J , Liotta MA , Harper CM , Harris CC . Chemical carcinogeninduced decreases in genomic 5-methyldeoxycytidine content of normal bronchial epithelial cells . Proc Natl Acad Sci USA. 1987; 84: 3298-3301 .
