1 Foy BD , Toxopeus C , Frazier JM . Kinetic modeling of slow dissociation of bromosulphophthalein from albumin in perfused rat liver: toxicological implications . Toxicological Science1999; 50: 20-29 .
2.
2 Rosenkranz HS et al. Development, characterization and application of predictive-toxicology models . SAR QSAR Environmental Reseach1999; 10: 277-298 .
3.
3 Haddad S , Tardif R , Viau C , Krishnan K . A modeling approach to account for toxicokinetic interactions in the calculation of biological hazard index for chemical mixtures . Toxicological Letter1999; 108: 303-308 .
4.
4 Brinkworth MH , Anderson D . An evaluation of two animal models for dietary influences on reproductive toxicology . In Vivo1991; 5: 153-157 .
5.
5 Morgan LR et al. Comparative preclinical toxicology and pharmacology of 4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007) in vitro and in rodents and primates . In Vivo1997; 11: 29-37 .
6.
6 Peter R et al. Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1 . Chemical Research in Toxicology1990; 3: 566-573 .
7.
7 Vesell ES , Seaton TD , A-Rahim YI . Studies on interindividual variations of CYP2E1 using chlorzoxazone as an in vivo probe . Pharmacogenetics1995; 5: 53-57 .
8.
8 Bachmann K , Sarver JG . Chlorzoxazone as a single sample probe of hepatic CYP2E1 activity in humans . Pharmacology1996; 52: 169-177 .
9.
9 Koop DR . Oxidative and reductive metabolism by cytochrome P450 2E1 . FASEB Journal1992; 6: 724-730 .
10.
10 Raucy JL . Risk assessment: toxicity from chemical exposure resulting from enhanced expression of CYP2E1 . Toxicology1995; 105: 217-224 .
11.
11 Song BJ . Ethanol-inducible cytochrome P450 (CYP2E1): biochemistry, molecular biology and clinical relevance: 1996 up-date . Alcoholism, Clinical and Experimental Research1996; 20: 138A-146A .
12.
12 Raucy JL , Lasker JM , Lieber CS , Black M . Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2 . Archives of Biochemistry & Biophysics1989; 271: 270-283 .
13.
13 Spracklin DK et al. Cytochrome P450 2E1 is the principal catalyst of human oxidative halothane metabolism in vitro . Journal of Pharmacology & Experimental Therapeutics1997; 281: 400-411 .
14.
14 Kharasch ED , Thummel KE , Mautz D , Bosse S . Clinical enflurane metabolism by cytochrome P450 2E1 . Clinical Pharmacology & Therapeutics1994; 55: 434-440 .
15.
15 Kharasch ED , Thummel KE . Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane . Anesthesiology1993; 79: 795-807 .
16.
16 Tanaka E . In vivo age-related changes in hepatic drug-oxidizing capacity in humans . Journal of Clinical Pharmacy & Therapeutics1998; 23: 247-255 .
17.
17 Hakkola J , Tanaka E , Pelkonen O . Developmental expression of cytochrome P450 enzymes in human liver . Pharmacology & Toxicology1998; 82: 209-217 .
18.
18 Tanaka E . Gender-related differences in pharmacokinetics and their clinical significance . Journal of Clinical Pharmacy & Therapeutics1999; 24: 339-346 .
19.
19 Ono S et al. Chlorzoxazone is metabolized by human CYP1A2 as well as by human CYP2E1 . Pharmacogenetics1995; 5: 143-150 .
20.
20 Imai Y , Ito A , Sato R . Evidence for biochemically different type of vesicles in the hepatic microsomal function . Journal of Biochemistry1996; 60: 417-438 .
21.
21 Prough RA , Ziegler DM . The relative participation of liver microsomal amine oxidase and cytochrome P-450 in N-demethylation reactions . Archives of Biochemistry & Biophysics1977; 180: 363-373 .
22.
22 Omura T , Sato R . The carbon monoxide binding pigment of liver microsomes,. Evidence for its hemoprotein nature . Journal of Biological Chemistry1964; 239: 2370-2378 .
23.
23 Guengerich FP , Wang P , Davidson NK . Estimation of isozymes of microsomal cytochrome P-450 in rats, rabbits, and humans using immunochemical staining coupled with sodium dodecyl sulfate-polyacrylamide gel electrophoresis . Biochemistry1982; 21: 1698-1706 .
24.
24 Lowry OH , Rosebrough NJ , Farr AL , Randall RJ . Protein measurement with Folin phenol reagent . Journal of Biological Chemistry1951; 193: 265-275 .
25.
25 Girre C et al. Assessment of cytochrome P4502E1 induction in alcoholic patients by chlorzoxazone pharmacokinetics . Biochemical Pharmacology1994; 47: 1503-1508 .
26.
26 Raucy JL et al. Human lymphocyte cytochrome P450 2E1, a putative marker for alcohol-mediated changes in hepatic chlorzoxazone activity . Drug Metabolism & Disposition1997; 25: 1429-1435 .
27.
27 Dilger K , Metzler J , Bode JC , Klotz U . CYP2E1 activity in patients with alcoholic liver disease . Journal of Hepatology1997; 27: 1009-1014 .
28.
28 Mishin VM et al. Chlorzoxazone pharmacokinetics as a marker of hepatic cytochrome P4502E1 in humans . American Journal of Gastroenterology1998: 93: 2154-2161 .
29.
29 Lucas D et al. Cytochrome P450 2E1 activity in diabetic and obese patients as assessed by chlorzoxazone hydroxylation . Fundamental & Clinical Pharmacology1998; 12: 553-558 .
30.
30 McCarver DG et al. A genetic polymorphism in the regulatory sequences of human CYP2E1: association with increased chlorzoxazone hydroxylation in the presence of obesity and ethanol intake . Toxicology and Applied Pharmacology1998; 152: 276-281 .
31.
31 Shimada T et al. Cytochrome P450-dependent drug oxidation activities in liver microsomes of various animal species including rats, guinea pigs, dogs, monkeys, and humans . Archives of Toxicology1997; 71: 401-408 .
32.
32 Amato G , Longo V , Mazzaccaro A , Gervasi PG . Chlorzoxazone 6-hydroxylase and p-nitrophenol hydroxylase as the most suitable activities for assaying cytochrome P450 2E1 in cynomolgus monkey liver . Drug Metabolism & Disposition1998; 26: 483-489 .
33.
33 Shapiro BH , Agrawal AK , Pampori NA . Gender differences in drug metabolism regulated by growth hormone . International Journal of Biochemistry & Cell Biology, 1995; 27: 9-20 .
34.
34 Kato R , Yamazoe Y . Sex-specific cytochrome P450 as a cause of sex- and species-related differences in drug toxicity . Toxicology Letters1992; 64-65: 661-667 .
35.
35 Imaoka S , Fujita S , Funae Y . Age-dependent expression of cytochrome P-450s in rat liver . Biochimica et Biophysica Acta1991; 1097: 187-192 .
36.
36 Chengelis CP . Age- and sex-related changes in the components of the hepatic microsomal mixed function oxidase system in Sprague-Dawley rats . Xenobiotica1988; 18: 1211-1224 .
37.
37 Fujita S et al. Alteration of plasma sex hormone levels associated with old age and its effect on hepatic drug metabolism in rats . Journal of Pharmacology & Experimental Therapeutics1990; 253: 369-374 .