Subclinical, repeated exposures of F344 rats to sarin resulted in brain alterations in densities of chlonergic receptor subtypes that may be associated with memory loss and cognitive dysfunction. The exposures also depressed the immune system. The rat appears to be a good model for studying the effects of subclinical exposure to a nerve gas.
Conn, C. A., Dokladny, K., Meânache, M. G., Barr, E. B., Kozak, W., Kozak, A., Wachulec, M., Rudolph, K., Kluger, M. J. and Henderson, R. F.2002: Effects of sarin inhalation on body temperature and locomotor activity of rats. Toxicology and Applied Pharmacology184, 77-81.
2.
Henderson, R. F., Barr, E. B., Blackwell, W. B., Clark, C. R., Conn, C. A., Kalra, R., March, T. H., Sopori, M. L., Tesfaigzi, Y., Meânache, M. G. and Mash, D. C.2002: Response of rats to low levels of sarin. Toxicology and Applied Pharmacology184, 67-76.
3.
Kalra, R., Singh, S. P., Razani-Boroujerdi, S., Langley, R. J., Blackwell, W. B., Henderson, R. F., and Sopori, M. L.2002: Subclinical doses of the nerve gas sarin impair T cell responses through the autonomic nervous system. Toxicology and Applied Pharmacology184, 82-87.
