Cachexia and omega-3 polyunsaturated fatty acids: the beginning of the end or the end of the beginning?

Scott HR , McMillan DC , Forrest LM , Brown DJF , McArdle CS , Milroy R . The systemic inflammatory response, weight loss, performance status and survival in patients with inoperable non-small cell lung cancer . Br J Cancer 2002; 87: 264–267 .

Barber MD , Fearon KCH , Tisdale MJ , McMillan DC , Ross JA . Effect of a fish oil-enriched nutritional supplement on metabolic mediators in patients with pancreatic cancer cachexia . Nutr Cancer 2001; 40: 118–124 .

Tisdale MJ . Cachexia in cancer patients . Nat Rev Cancer 2002; 2: 862–871 .

Tisdale MJ . The ‘cancer cachectic factor’ . Support Care Cancer 2003; 11: 73–78 .

Grimble RF . Nutritional therapy for cancer cachexia . Gut 2003; 52: 1391–1392 .

Barber MD , Ross JA , Voss AC , Tisdale MJ , Fearon KCH . The effect of an oral nutritional supplement enriched with fish oil on weight-loss in patients with pancreatic cancer . Br J Cancer 1999; 81: 80–86 .

Fearon KCH , von Meyenfeldt MF , Moses AGW , et al. Effect of a protein and energy dense n-3 fatty acid enriched oral supplement on loss of weight and lean tissue in cancer cachexia: a randomised double blind trial . Gut 2003; 52: 1479–1486 .

Jatoi A , Rowland K , Loprinzi CL , et al. An eicosapentaenoic acid supplement versus megesterol acetate versus both for patients with cancer associated wasting: a north central cancer treatment group and national cancer institute of Canada collaborative effort . J Clin Oncol 2004; 22: 2469–2476 .

Wigmore SJ , Ross JA , Falconer JS , et al. The effect of polyunsaturated fatty acids on the progress of cachexia in patients with pancreatic cancer . Nutrition 1996; 12 Suppl: s27–s30 .

Ross Products Division , Abbott Laboratories . Personal communication, 2005.

Jatoi A . Personal communication, 2005.

Moses AWG , Slater C , Preston T , Barber MD , Fearon KCH . Reduced total energy expenditure and physical activity in cachectic patients with pancreatic cancer can be modulated by an energy and protein dense oral supplement enriched with n-3 fatty acids . Br J Cancer 2004; 90: 996–1002 .

Dahele M , Fearon KCH . Research methodology: cancer cachexia syndrome . Palliat Med 2004; 18: 409–417 .

Lundholm K , Daneryd P , Körner U , Hyltander A , Bosaeus I . Evidence that long-term COX-treatment improves energy homeostasis and body composition in cancer patients with cachexia . Int J Oncol 2004; 24: 505–512 .