Clinical research in palliative care: choice of trial design

MacDonald N , Bruera E . Clinical trials in cancer pain research. In: Foley K , Portenoy RK eds. Advances in pain research and therapy, Vol. 16. New York: Raven Press, 1990: 443–449.

Bruera E . Cancer pain: chronic studies of adjuvants to opiate analgesics. In: Max MB , Portenoy RK , Laska EM eds. Advances in pain research and therapy. The design of analgesic trials, Vol. 18. New York: Raven Press, 1991: 267–281.

Bruera E . Research in symptoms other than pain. In: Doyle D , Hanks GW , MacDonald N eds. The Oxford textbook of palliative medicine, 2nd edition. London: Oxford University Press, 1998: 179–185.

Bruera E , Pereira J . The research palliative care unit. In: Von Guten CF , ed. Palliative care and rehabilitation of cancer patients. Boston, MA: Kluwer Academic, 1999: 161–183.

Mazzocato C , Sweeney C , Bruera E . Clinical research in palliative care: patient populations, interventions and endpoints. Palliat Med 2001; 15: 163–168.

Bruera E , Brenneis C , Michaud M . Use of the subcutaneous route for the administration of narcotics in patients with cancer pain. Cancer 1988; 62: 407–411.

Bruera E , Schoeller T , MacEachern T . Symptomatic benefit of supplemental oxygen in hypoxemic patients with terminal cancer: the use of the N of 1 randomized controlled trial. J Pain Symptom Manage 1992; 7: 365–368.

Woodcock AA , Gross ER , Gellert A , Shah S , Johnson M , Geddes DM . Effects of dihydrocodeine, alcohol and caffeine on breathlessness and exercise tolerance in patients with chronic obstructive lung disease and normal blood gases. N Engl J Med 1981; 305: 1611–1616.

Woodcock A , Gross E , Geddes DM . Drug treatment of breathlessness: contrasting of diazepam and promethazine in pink puffers. Br Med J 1981; 283: 343–346.

Watson CP , Evans RJ , Reed K , Merskey H , Goldsmith L , Warsh J . Amitriptyline versus placebo in postherpetic neuralgia. Neurology 1982; 32: 671–673.