Coating of extracorporeal circuits may be a solution to prevent adverse effects
induced by the contact of blood elements and proteins with foreign surfaces. This
paper reviews the recent novel coating technologies and compares their documented
in vitro and ex vivo advantages under the clinical setting.
Data presented have also been supported by postclinical biomaterial research to
verify biocompatibility and hemocompatibility.
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References
1.
Janvier G, Baquey C, Roth C, Benillan N, Belisle S, Hardy JF.Extracorporeal circulation, hemocompatibility, and biomaterials. Ann Thorac Surg1996; 62: 1926-1934.
2.
Courtney JM, Zhao XB, Quian H, Sharma A.Modification of polymer surfaces: optimization of approaches. Perfusion2003; 18: 33-39.
3.
Engbers GH, Feijen J.Current techniques to improve the blood compatibility of biomaterial surfaces. Int J Artif Organs1991; 14: 199-215.
Wendel HP, Ziemer G.Coating techniques to improve hemocompatibility of artificial devices used
for extra-corporeal circulation. Eur J Cardiothorac Surg1999; 16: 342-350.
6.
Sinci V, KalayciuSglu S, Gunaydin Set al.Evaluation of heparin-coated circuits with full heparin dose strategy. Ann Thorac Cardiovasc Surg1999; 5: 156-163.
7.
Griffith KE, Vasquez MR, Beckly PD, Lalone BJ.Predicting oxygenator clinical performance from laboratory in vitro setting. J Extra Corpor Technol1994; 26: 114-120.
8.
Tanaka M, Motomura T, Kawada Met al.Blood compatible aspects of poly(2-methoxyethylacrylate) relationship
between protein adsorption and platelet adhesion on PMEA surface. Biomaterials2000; 21: 1471-1481.
9.
Gu YJ, Boonstra PW, Rijnsburger AAet al.Cardiopulmonary bypass circuit treated with surface modifying additives: a
clinical evaluation of blood compatibility. Ann Thorac Surg1998; 65: 1342-1347.
10.
Gourlay T.Biomaterial development for cardiopulmonary bypass. Perfusion2001; 16: 381-390.
11.
Stammers AH.Biocompatibility of Trillium biopassive surface coated oxygenator during
cardiopulmonary bypass. J Cardiothorac Vasc Anesth2001; 15: 539-541.
Gunaydin S, Farsak B, Kocakulak M, Sari T, Yorgancioglu C, Zorlutuna Y.Clinical performance and biocompatibility of poly (2-methoxyethylacrylate)
coated extracorporeal circuits. Ann Thorac Surg2002; 74: 819-824.
14.
Kocakulak M, Kocum C, Saber Ret al.Investigation of blood compatibility of PMEA coated extracorporeal circuits. J Bioact Compat Poly2002; 17: 343-356.
15.
Tevaearai HT, Mueller XM, Seigneul Iet al.Trillium coating of cardiopulmonary bypass circuits improves biocompatibility. Int J Artif Organs1999; 22: 629-634.
16.
Ereth MH, Nuttall GA, Clarke SHet al.Biocompatibility of Trillium biopassive surface coated oxygenator versus
uncoated oxygenator during cardiopulmonary bypass. J Cardiothorac Vasc Anesth2001; 15: 545-550.
17.
De Somer F, Francois K, van Oeveren W.Phosphor-ylcholine coating of extracorporeal circuits provides natural
protection against blood activation by the material surface. Eur J Cardiothorac Surg2000; 18: 602-606.
18.
Courtney JM, Lamba NMK, Gaylor JDS, Ryan CJ, Lowe GDO.Blood contacting biomaterials: bioengineering viewpoints. Artif Organs1995; 19: 852-856.
19.
Vijay V, McCusker K.Recent advances in biocompatible surface-modifying additives for
cardiopulmonary bypass. Perfusion2003; 18: 41-45.
20.
Harig F, Hohenstein B, von der Emde Jet al.Modulating IL-6 and IL-10 levels of pharmacologic strategies and the impact
of different extracorporeal circulation parameters during cardiac surgery. Shock2001; 16: 33-38.
21.
Rega FR, Vandezande EJ, Jannis NC, Verleden GM, Lerut TE, Van Raemdonck D.The role of leukocyte depletion in ex vivo evaluation of pulmonary grafts
from non-heart beating donors. Perfusion2003; 18: 13-21.
